Enterococcus faecalis

Enterobacter aerogenes Enterobacter cloacae Enterobacteriaceae Enterobacter ridant Enterobactin Enterococcus faecalis Enterohepatitis Enteroviruses... 

Other pseudomonic acids (B, C, D) are also produced. Mupirocin is active predominantly against staphylococci and most streptococci, but Enterococcus faecalis and Gramnegative bacilli are resistant There is also evidence of plasmid-mediated mupirocin resistance in some chnical isolates of Staph, aureus. 

Bacteria which are almost always sensitive to the sulphonamides include Strep, pneumoniae, /3-haemolytic streptococci, Escherichia coli and Proteus mirabilis those almost always resistant include Enterococcus faecalis, Ps. aeruginosa, indole-positive Proteus and Klebsiella whereas bacteria showing a marked variation in response include Staph, aureus, gonococci, El. influenzae and hospital strains of E. coli and Pr. mirabilis. 

Chen, H. Wang, R. Cerniglia, C. E. Molecular cloning, overexpression, purification, and characterization of an aerobic FMN-dependent azoreductase from Enterococcus faecalis. Protein Expression Purif. 2004,34, 302-310. 

Snoep, J.L., de Graef, M.R., Westphal, A.H., de Kok, A., Teixeira, de Mattos, M.J. and Neijssel, O.M. (1993) Differences in sensitivity to NADH of purified pyruvate dehydrogenase complexes of Enterococcus faecalis, Lactococcus lactis, Azotobacter vinelandii and Escherichia colt, implications for their activity in vivo. FEMS Microbiology Letters 114, 279-283. 

An interesting example of DNA damage by superoxide and hydrogen peroxide produced by microbes has been recently described by Huycke et al. [49]. These authors have showed that reactive oxygen species produced by Enterococcus faecalis, a microorganism of the human intestinal tract, oxidized DNA in Chinese hamster ovary and intestinal epithelial cells. 

Enterococcus faecalis (generally not as resistant to antibiotics as Enterococcus faea um)... 

Complicated coli Proteus mirabiiis Klebisella pneumoniae Pseudomonas aeruginosa Enterococcus faecalis 1. Quinolone x 14 days (B, III)0 2. Extended-spectrum penicillin plus aminoglycoside (B, III)0 Severity of illness will determine duration of IV therapy culture results should direct therapy Oral therapy may complete 14 days of therapy... 

Finally, the antifungal properties of a-pinene and limonene, two monoter-penes frequently found in the defensive secretion of Nasutitermes termites, was studied. In vitro assays showed that these molecules reduce spore germination of the fungus Metarhizium anisopliae through direct and indirect (vapor) contact [225]. Moreover, some diterpenes isolated from these insects have also an antibiotic activity on Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis [226]. 

Standard and the isolated strains of the following bacteria, namely Escherichia coli (ATCC 35218), Pseudomonas aeruginosa (ATCC 10145), Proteus mirabilis (ATCC 7002), Klebsiella pneumoniae (RSKK 574), Acinetobacter baumannii (RSKK 02026), Staphylococcus aureus (ATCC 25923), and Enterococcus faecalis (ATCC 29212) for determination of antibacterial activity, along with standard strains of Candida albicans (ATCC 10231) and C. parapsilosis (ATCC 22019) were used for determination of antifungal activity. 

Virulence Regulation in Enterococcus faecalis by Peptide Signaling 315... 

Pheromone-Responding Conjugative Plasmids in Enterococcus faecalis 316... 

Table 4 Conjugal plasmids and their peptide pheromones in Enterococcus faecalis ...

In order to analyze the effect that conformational restriction has on the antibiotic enzymatic inactivation, three different enzymes were chosen as model systems Staphylococcus aureus ANT(4 ), Mycobacterium tuberculosis AAC(2 ) and Enterococcus faecalis APH(3 ). These proteins are representative of the three main families of enzymes that modify aminoglycosides adenyltrans-ferases, acyltransferases and phosphotransferases. In addition, there is high resolution X-ray structural information available for the three enzymes in complex with several antibiotics. 

Finally, the effect of neomycin-B flexibility on its enzymatic inactivation by Enterococcus faecalis APH(3 ) was tested. This enzyme catalyzes the transfer of a phosphate group from ATP to position 4 of ring I. In this case, the X-ray structure of the enzyme in complex with neomycin-B shows that the antibiotic structure recognized by the enzyme and the target RNA are remarkably similar (see Fig. 7) [40]. In fact, they mainly differ in the conformation adopted by the furanose ring of III (C3-endo and close to C2-endo for the RNA- and enzyme-bound conformations respectively). 

Bacteroides fragilis Prevotella intermedia Enterococcus faecalis A Enterococcus faecalis B... 

Figure 3.5. Aminoglycoside kinases are members of the protein kinase family. Comparison of c-AMP-dependent protein kinase (cAPK) to APH(3 )-IIa and APH(3 )-IIIa. (A) cAPK (catalytic domain) from Mus musculus (pdb ID 2CPK). (B) APH(3 )-IIa from Klebsiella pneumoniae (pdb ID 1ND4). (C) APH(3 )-IIIa from Enterococcus faecalis (pdb ID 1L8T).

Urinary tract infections (complicated and uncomplicated) - Enterococcus faecalis, S. awrews (penicillinase-producing), E. coli, Klebsiella sp.,... 

Intra-abdominal Infections - Enterococcus faecalis, S. aureus (penicillinase-producing), Staphylococcus epidermidis, E. coli, Klebsiella sp., Enterobacter sp., Proteus sp., M. morganii, P. aeruginosa, Citrobactersp., Clostridium sp., Bacteroides sp. including Bacteroides fragilis, Fusobacterium sp. Peptococcus sp., Peptostreptococcus sp., Eubacterium sp., Proplonibacterium sp.. Bifidobacterium sp. 

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