Staphylococcus aureus antibacterial activity against

Tolypomycin Y (48) shows strong antibacterial activity against gram-positive bacteria and Neisseriagonorrheae. When adininistered by subcutaneous, intraperitoneal, and intravenous routes, tolypomycin Y is effective in mice infected with Staphylococcus aureus Streptococcuspyrogenes and Diplococcuspneumoniae. Cross-resistance is observed with rifampicia but not with other antibiotics. Resistance to tolypomycin Y develops rapidly. The bioactivity of tolypomycin R... 

The pyridazino[6,l-A quinazoline 114 (Ar = 4-biphenyl) exhibited high in vitro antibacterial activity against Staphylococcus aureus and anifungal activity against Aspergillus fumigatus <2001RRC649>. 

Twenty-five dibenzothiophenes, composed mainly of amino and acetamidodibenzothiophenes and their sulfoxides and sulfones, have been tested for antibacterial activity against Staphylococcus aureus, Escherichia coli, and Mycobacterium tuberculosis. Activity was found against the latter with 2- and 3-aminodibenzothiophene in synthetic culture media, but the effect was reversed by the addition of serum. " ... 

Some of the prenylated and lavandulylated flavanones from S. flavescens, kushenols P-S, exhibited significant antibacterial activities against the Gram-positive bacteria, Staphylococcus aureus, S. epidermidis. Bacillus subtilis, and Propionibacterium acnes. They also exhibited antiandrogenic activities. Kurarinone (114), 2 -(9-methylkurarinone (115), and the known sophoraflavanone G and leachianone A from the roots of S, flavescens, which all have 8-lavandulyl substitution and 2, 4 -di-(9-substitution of the B-ring, exhibited cytotoxic activity... 

Altematamides A-C (92-94), bromotryptamine peptides from the Atlantic bryozoan Amathia alternata, show modest antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis,... 

Interestingly, the undifferentiated antibacterial activity against both methicillin-susceptible and -resistant strains of Staphylococcus aureus was suggestive of an alternative mechanism of action compared to that of typical (3-lactams. The molecular modeling approach allowed the identification of interactions through oxygenated functions such as phenolic OH, which are valuable for the antibacterial activity [294]. 

The introduction of a fluorine atom at the C-l methyl group in the thiazetoquinolone 223 should enhance the in vitro and in vivo antibacterial activity against various bacteria including quinolone-resistant methicillin-resistant Staphylococcus aureus (MRSA) and also improve its bioavailability <1999CPB1765>. 

The antibacterial activity of homogenized seed oil and residues indicates that the powdered seeds of C. copticum exhibit antibacterial activity against Staphylococcus aureus only and not E. coli. The oil extracted with n-hexane exhibited antibacterial activity against both organisms, while the oil extracted with ethanol and n-hexane did not. The residue left after ethanol extraction exhibits antibacterial activity against E. coli only (Qasim and Khan, 2001). 

Jarvest, R.L. et al. 2002. Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. J. Med. Chem. 45, 1959-1962. 

Daphneticin (12), isolated from the leaves of Daphne gnidium, has been reported to possess moderate antibacterial activity against Staphylococcus aureus and Bacillus cereus (66). Cheng and Chen demonstrated that the coumarinolignans, aquillochin (7), cleomiscosin A (9), and 5 -demethyl aquillochin (14) were active against HIV (41). 

Marasmic acid (13) was isolated from the basidiomycete Marasmium conigenus (mold). This compound possesses potent antibacterial activity against Staphylococcus aureus and E. coli although no mechanism of action has been established. 

EtOAc extract of a marine Bacillus sp. Sc026 culture broth, in bioactivity-guided fractionation, led to the isolation of two new compounds, 7-O-succinyl macrolactin F 229 and 7-(9-succinyl macrolactin A 230. Both exhibited antibacterial activity against Bacillus subtilis and Staphylococcus aureus, (inhibition zones of 8-28 mm at 50-100 pg/disk). 

Seven new macrolactins G-M 231-237 were isolated from a culture broth of bacillus sp. PP19-H3. The strain was isolated from macroalga Schizyvenia dubyi collected from the Omaezaki coast of Shizuoka prefecture in Japan. All compounds were examined and showed relatively weak antibacterial activities against bacteria Staphylococcus aureus (IFW 12732) and Bacillus subtilis (IFO 3134). 

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