Plasmodium genus

That an effective vaccine, even one that only responds to certain Plasmodium strains, has not been developed has been puzzling, in that the human immune system does adapt with immunoglohulin-pnxiucing B cells and T cells that respond to processed antigen. The innate side of the immune sy.stem also responds. In other words, the human immune system responds to the various forms of the Plasmodium paiusite just as it does to other parasites. It has been suggested that just as the Plasmodium genus has adapted to humans, humans have adapted to the parasite. The five human mutations mentioned above arc one example. There may be others. 

Malaria is transmitted by the bite of an infected female Anopheles mosquito, one of the few species of the insect capable of carrying the human malaria parasite. The responsible protozoa ate from the genus P/asmodium of which only four of some 100 species can cause the disease in humans. The remaining species affect rodents, reptiles, monkeys, birds, and Hvestock. The species that infect humans are P/asmodium falciparum Plasmodium vivax Plasmodium malariae and Plasmodium ovale. Note that concomitant multiple malaria infections are commonly seen in endemic areas, a phenomenon that further compHcates choice of treatment. 

Four different protozoa of the genus Plasmodium -P. falciparum, P. vivax, P. ovale and P malariae - can cause malaria. P. falciparum is the most virulent, being responsible for virtually all fatal malaria cases. Humans are infected by a feeding female Anopheles mosquito (Fig. 2). The clinical symptoms of malaria are associated with the development of the parasite within human red blood cells, while the liver stages remain asymptomatic. The following dtugs (in alphabetical order) are currently in use for the treatment of malaria [5]. 

Malaria remains a major public health problem in many parts of the world, including Southeast Asia, sub-Saharan Africa and Latin America where an estimated 300-500 million people are infected. 1-3 million die of malaria every year. The etiologic agents of malaria are protozoan parasites of the genus Plasmodium. Of the four pathogens that can cause malaria in humans (Plasmodium falciparum, P. vivax, P. ovale,... 

Malaria, a tropical disease caused by protozoan parasites of the genus Plasmodium, has been a major concern for centuries and has now extended to a great deal of the world s population, killing every year 1-2 million people. Different medicines are in use to cure or to prevent malaria. The classical natural medicine quinine was soon replenished with synthetic compounds such as primaquine, chloroquine and mefloquine. However, a major problem is still an increasing resistance towards these compounds. 

Malaria. An infectious disease endemic in parts of Africa, Asia, Turkey, the West Indies, Central and South America, and Oceania, caused by protozoa of the genus Plasmodium, and usually transmitted by the bites of infected anopheline mosquitoes. It is characterized by prostration associated with paroxysms of high fever, shaking chills, sweating, anemia, and splenomegaly, which may lead to death. 

Tiny ameboid parasites of the subphylum Sporozoa attack members of all other animal phyla. Several genera of Coccidia parasitize rabbits and poultry causing enormous damage. Humans are often the victims of species of the genus Plasmodium (Fig. 1-9) which invade red blood cells and other tissues to cause... 

The causative organisms of malaria are protozoa of the genus Plasmodium, with four species known to infect humans only ... 

Malaria is a disease caused by eukaryotic protists of the genus Plasmodium. Of the Plasmodium species, P. falciparum is the most dangerous, responsible for the vast majority of malaria infections and deaths. Roughly two million people die every year from malaria [27],... 

Malaria is a devastating disease caused by protozoan parasites from the genus Plasmodium. While reported cases of malaria decreased by 50% between 2000 and 2010, 216 million cases and almost 700,000 malaria-related deaths were reported in 2010 (1). In addition, 86% of these malaria deaths claimed the lives of children under 5 years of age. The African Region continues to bear the brunt of the malaria burden with an estimated 81% of all reported malaria cases. In general, tropical and subtropical regions have the greatest rates of malaria transmission as the climate in these regions supports development of the mosquito vector. 

Four principal species from the genus Plasmodium cause natural human infection Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium falciparum. P. falciparum is the most lethal as it causes approximately 90% of malaria-related deaths (1). An additional species, Plasmodium knowlesi, which generally infects macaques, has also been shown increasingly to infect humans as well (4). As more sophisticated diagnostic tests are now able to easily distinguish one species of Plasmodium from another, it is thought that infection with P. knowlesi has heretofore been underreported because this species morphologically resembles other Plasmodium species in blood smears (5). 

The life cycle of Plasmodium requires two vectors for completion. The definitive hosts are female mosquitoes from the genus Anopheles. Anophelesgambiae and Anopheles funestus are two such definitive hosts in the African Region, while Anopheles darlingi transmits malaria in South and Central America (6-8). The second host is a vertebrate that may be a bird, reptile, or small mammal. The malaria species listed above are all able to utilize humans as a vertebrate host. 

Malaria is one of the world s most serious human health problems. According to the World Health Organization, more than 200 million new infections occur each year, many resulting in death [66]. The disease is caused by protozoa of the genus Plasmodium, most notably P. falciparum, which live in the intestines of female Anopheles mosquitoes. Humans are infected by bites from infected mosquitoes, by blood transfusions from infected donors, or by an expectant mother transmitting the disease to her child. Malaria is endemic in Sub-Saharan Africa, Central and South America, the Indian subcontinent and Oceania [67]. 

Malaria is caused by a one-celled parasite from the genus Plasmodium. Four species of Plasmodium infect humans, each appearing somewhat different under the microscope and producing somewhat different clinical presentations. Two or more species can live in the same area and can infect a single individual at the same time (National Institute of Allergy and Infectious Diseases, 2002). The four species are as follows ... 

A number of species of Plasmodium invade the blood and liver causing malaria in man and animals. The important pathogens of malaria in man are Plasmodium falciparum, P. vivax, P. ovale and P. malariae. The disease is transmitted to man by female mosquitoes belonging to the genus Anopheles and is endemic in several parts of Asia, Africa and South America. 

MALARIA is a disease mostly in tropical areas, where it is a major medical problem. Malaria is caused by a parasitic protozoa of the genus Plasmodium and is transferred when an infected female mosquito of the genus Anopheles bites a person and Plasmodium sporozoites enter the blood, where they first reach the liver and develop into merozoites over a period of 5-7 days without giving any symptoms. Then the immature merozoites penetrate the red blood corpuscles, where they divide asexually to form merozoites. When this process is complete, the blood corpuscles rupture and the merozoites enter the blood plasma. The rupture of the erythrocyte membrane provokes a fever, which occurs every second day after infection with Plasmodium vivax, every third after infection with Plasmodium malaria after infection with the severe Plasmodium falciparum fever is more irregular, because the parasites of this species do not develop simultaneously. 

Malaria parasitic condition due to the development and multiplication of hematozygotes of the genus Plasmodium. 

Members of the genus Plasmodium are obligate intra-erythrocytic parasites. Hemoglobin, the predominant soluble cytoplasmic protein of the erythrocyte, can be an abundant and vital nutrient source for the plasmo-dia when they are able to degrade and assimilate the resultant peptides and amino acids. This being so it would seem, a priori, that plasmodial hemoglobinases would be suitable targets for potential anti-malarials. 

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