Natural medicinals

Zaitseva, M., Blauvelt, A., Lee, S., Lapham, C. K., Klaus-Kovtun, V., Mostowski, H., Manischewitz, J., and Golding, H. (1997). Expression and function of CCR5 and CXCR4 on human langerhans cells and macrophages Implications for HIV primary infection. Nature Medicine 3 1369-1375. 

Kotler, D. P., Wolinsky, S. M., and Koup, R. A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Medicine 2 412-417. 

Kiyohara H (1998) In AgetaH, AimiN, EbizukaY, FujitaT, Honda G (eds) Towards Natural Medicine Research in the 21st Centiuy. Elsevier Science, Amsterdam, p 161... 

Brigitte Mars, an herbalist and nutritional consultant in Boulder, Colorado, has been working with natural medicines for over 27 years. The formulator of the popular "UniTea" line of herbal teas, she teaches herbalism at Naropa Institute, The Rocky Mountain Center for Botanical Studies and The Boulder School of Massage Therapy. She frequently contributes articles to The Herb Companion, Natural Health, Let s Live, and other magazines, and is a member of the American Herbalist Guild. This is her first book. 

In natural medicine, people and plants are viewed as connected to each other as well as to the environment. 

Jellin JM, ed. Natural Medicines Comprehensive Database. Stockton, CA Therapeutic Research Faculty, 2001. 

Fox, J.G., Beck, P., Dangler, C.A., Whary, M.T., Wang, T.C., Shi, H.N. and Nagler-Anderson, C. (2000) Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nature Medicine 6, 536-542. 

Jellin, Jeff M. Natural Medicine Comprehensive Database 2004, 6th ed. Stockton Therapeutic Research Center, 2004. 

Collen, D. 1998. Staphylokinase a potent, uniquely fibrin-selective thrombolytic agent. Nature Medicine 4(3), 279-284. 

Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JP, deSolms SJ, Guiliani EA, Gomez RP, Graham SL (1995) Nature Medicine 1 792... 

KUSHIRO, T., SHIBUYA, M., EBIZUKA, Y., Molecular cloning of oxidosqualene cyclase cDNA from Panax ginseng The isogene that encodes P-amyrin synthase. In Towards Natural Medicine Research in the 21st Century, (H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita and G. Honda, eds,), Elsevier Science, Amsterdam. 1998, pp. 421-427. 

Synold, T.W., Dussault, I. and Forman, B.M. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nature Medicine, 7, 584-590. 

Malaria, a tropical disease caused by protozoan parasites of the genus Plasmodium, has been a major concern for centuries and has now extended to a great deal of the world s population, killing every year 1-2 million people. Different medicines are in use to cure or to prevent malaria. The classical natural medicine quinine was soon replenished with synthetic compounds such as primaquine, chloroquine and mefloquine. However, a major problem is still an increasing resistance towards these compounds. 

Ironically, by the time DSHEA was enacted, the OTC drug review had rid the marketplace of nearly all fhe sfandard OTC products that had been marketed with unsubstantiated claims. In contrast, few diefary supplements promoted with disease-related claims can live up to such claims. A few years ago, a review of 964 herbs and diefary supplemenf products listed in the Natural Medicines Comprehensive Database found fhaf only 15% had been proven safe and only 11% had been proven effective for the indications for which fhey were advocafed. ... 

The Natural Medicines Comprehensive Database contains more than 1000 monographs. It is available online or in print for 92 per year (or 132 for both versions). It provides information about more than 1000 herbal and dietary supplement ingredients. 

About Herbs, a project of Memorial Sloan-Kettering Cancer Center (New York, New York), evaluates more than 300 herbs, dietary supplements, and "alternative" cancer treatments. Both "professional" and consumer versions are provided, but most of the professional information is readily understandable by la5q>eople. The articles are shorter than their counterparts in the Natural Medicines database, but they are researched and written quite well. 

Marty, A.T., Natural medicines comprehensive database, JAMA, 283, 2992, 2000. 

Source Wickware R Resurrecting the resurrection drug, Nature Medicine 8 908-909 (2002). 

Kroemer, G., and Reed, J.C., 2000, Mitochondrial control of cell death. Nature Medicine 6 513-519. 

Chalhoub, N., Benachenhou, N., Rajapurohitam, V., Pata, M., Perron, M., Frattini, A., Villa, A., and Vacher, J. (2003) Grey-lethal Mutation Induces Severe Malignant Autosomal Recessive Osteopetrosis in Mouse and Human. Nature Medicine, 399-406. 

Matsuda H, Morikawa T, Yoshikawa M. (2002) Antidiabetogenic constituents from several natural medicines. Pure Appl Chem 74 1301-1308. 

Matsuda H, Nishida N, Yoshikawa M. (2002) Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2) structures of Myrciacitrins IB, IV, and V. Chem PharmBull 50 429 31. 

Yoshikawa M, Shimada H, Nishida N, Li Y, Toguchida I, Yamahara J, Matsuda H. (1998) Antidiabetic principles of natural medicines. II. Aldose reductase and a-glucosidase inhibitors from Brazilian natural medicine, the leaves of Myrcia multiflora DC. (Myrtacae) Structures of myrciacitrins I and II and myrciaphenones A and B. Chem Pharm Bull 46 113-119. 

Bremer C, Tung CH, Weissleder R (2001) Nature Medicine 7 743 Spikes JD (1990) J Photochem Photobiol B 6 259 Garbo GM (1996) J Photochem Photobiol B 34 109 Edrei R, Kimel S (1999) J Photochem Photobiol B 50 197 Sessler JL, MUler RA (2000) Biochem Pharmacol 59 733... 

Katz S, Harris R, Lau JT, Chau A, The use of gene expression analysis and proteomic databases in the development of a screening system to determine the value of natural medicinal products, Evid Based Complement Alternat Med 3 65-70,2006. 

Kim, C.W. and Kim, K.W. (2001) Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nature Medicine, 7, 437-443. 

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