Antigen processing

The exact molecular mode of action of this drug, which is so far only marketed in Japan, is not clear. Presumably, it interferes with antigen processing in APCs. 

Kloetzel PM Antigen processing by the protea-some. Nat Rev Mol Cell Biol 2001 2 179-187. 

Campbell R.D. Trowsdale J. (1993) Map ofthe human MHC. Immunol Today, 14, 349-352. Germain R.H. Marguiles D.M. (1993) The biochemistry and cell biology of antigen processing and presentation. Ann Rev11, 403-450. 

Bland, P.W. and Whiting, C.V. (1989) Antigen processing by rat intestinal villus enterocytes. Immunology 68, 497-502. 

Kuzushita N, Hayashi N, Kanto T, Ta-kehara T, Tatsumi T, Katayama K et al. Involvement of transporter associated with antigen processing 2 (TAP2] gene polymorphisms in hepatitis C virus infection. Gastroenterology 1999 116[5] 1149-1154. 

HSAB and sulfo-HSAB have been used to investigate serum amyloid A (Cai et al., 2007), the functional role of C-terminal sequence elements in the transporter associated with antigen processing (Ehses et al., 2005), and the kinetics of intermolecular interactions during cytochrome C protein folding (Nishida et al., 2004). 

The antiproliferative effects of arsenic are well documented. In vitro both divalent and pentavalent arsenicals inhibit murine [28] and bovine [18] phytohemaglutinin (PHA)-stimulated lymphoproliferation at concentrations of > 3 pM. Lymph node cells from arsenic treated, FTTC-sensitized mice displayed reduced lymphoproliferation in response to Con A, suggesting that the mechanism of antigen processing/presentation may be altered by arsenic exposure, inhibiting T-cell responsiveness [29], However, in vivo... 

Lewis, T., Hartmann, C. B., and McCoy, K. L., Gallium Arsenide Modulates Proteolytic Cathepsin Activities and Antigen Processing by Macrophages, J. Immunol., 161, 2151, 1998. 

Paulsson, K. (2004) Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery. Cell. Mol. Life Sci. 61, 2446-2460. 

Natural killer cells (NK) Reticuloendothelial CD14 HLA-DR Antigen processing, presentation, and phagocytosis (humoral and... 

Yamano, T. et al. Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class 1 antigen processing. J Exp Med 2002, 396, 185-96. 

During the last decade the MHC class 1 antigen processing machinery (APM) has been well defined and appears to be more complex than initially expected. It consists of four major steps (i) peptide generation and peptide trimming, (ii) peptide transport, (iii) MHC class 1 assembly and (iv) presentation of the trimeric MHC class 1 heavy chain/p2-m/peptide complex on the cell surface (Eigure 1). 

Abele, R., and Tampe, R., 2004, The ABCs of immunology structure and function of TAP, the transporter associated with antigen processing, Physiology (Bethesda) 19 216-224. 

Atkins, D., Ferrone, S., Schmahl, G. E., Storkel, S., and Seliger, B., 2004, Down-regulation of HLA class I antigen processing molecules an iimmme escape mechanism of renal cell carcinoma, / Urol. 171 885 889. 

Lou, Y., Vitalis, T. Z., Basha, G., Cai, B., Chen, S. S., Choi, K. B., Jeffries, A. P., Elliott, W. M., Atkins, D., Seliger, B., and Jefferies, W. A., 2005, Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival, Cancer Res. 65 7926-7933. 

Earner, E., and Cresswell, P., Mechanisms of MHC class 1-restricted antigen processing, 1998, Annu. Rev. Immunol. 16 323-358. 

Seliger, B., Maeurer, M. J., and Ferrone, S., 2000, Antigen-processing machinery breakdown and tumor growth, Immunol 7b[Pg.180]

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