Pancreas Tumors

Neutrotensin SCLC, colon tumors, exocrinic pancreas tumors... 

Gastric adenocarcinoma, GIT carcinoids, islet pancreas tumors, mucinous adenocarcinomas of ovary, bronchoalveolar carcinomas of lung, adenocarcinomas of urinary bladder... 

Despite recent developments, effectiveness of chemotherapy is still rather limited for most types of cancer, including tumors of the colon, lung, kidney, pancreas, and liver. Why some cancers respond better than others may be explained by factors relating to the anatomy and physiology of the cancer-ridden organ or... 

Zollinger-Ellison syndrome (ZES) is characterized by the development of a tumor (gastrinoma) or tumors that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach. In most cases, the tumor or tumors arise within the pancreas and/or the upper region of the small intestine (duodenum). 

Thus, there was a total of 8 rats for evaluation in the control group and 12 in the experimental group. In the control group given an extract of fish alone, there were no neoplastic changes in the stomach or pancreas except an epithelial hyperplasia of the glandular stomach of one rat (Table 1), Instead, there were tumors in the testes, kidneys, and soft tissues, as are often seen in aged rats. 

Kidney glomeruli, GI tract mucosa, exocrine and endocrine glands, certain tumors, pertibular capillaries, choroid plexus, pancreas, intestinal wall Sinusoidal... 

P-glycoprotein is not only expressed in tumor cells, but also in cells of several healthy tissues. In liver it was detected in the biliary canalicular surface of hepato-cytes and the apical surface of small biliary ductules. In the small intestine and colon, it is localized in the apical surface of columnar epithelial cells, and in kidneys it is found in the brush border membrane of proximal tubules. Moreover, it is detectable on the apical surface of small ductules in the pancreas and on the surface of cells in the medulla and cortex of adrenals [2]. 

Ectopic ACTH syndrome refers to excessive ACTH production resulting from an endocrine or nonendocrine tumor, usually of the pancreas, thyroid, or lung (e.g., small-cell lung cancer). 

Ten healthy rats were studies in total. Eight rats were treated with variable doses of coulombs and two rats were used as controls. ECT in the rat pancreas produced local necrosis and appears safe and reproducible in the healthy rat tissue the next step is to examine its feasibility in a pig model pancreas, before evaluating it clinically for pancreatic tumors. 

Gastrointestinal, pancreas, biliary, lung, transitional cell, sweat glands, mucosal squamous cell, mucinous carcinomas of female GU tract, medullary carcinoma of thyroid Breast, squamous cell, endometrioid, Brenner tumor Renal cell, hepatocellular, prostate, follicular thyroid, adrenal cortical, serous carcinomas of female GU tract, embryonal, yolk sac, mesothelioma... 

In rats, AAF had no demonstrable acute toxicity in quantities up to 50mg/kg subcutaneously and 1 g/% gastrically however, AAF was very toxic when administered in the diet." Incorporation of 0.031% AAF or higher for at least 95 days led to epithelial hyperplasia of the bladder, renal pelvis, liver, pancreas, and lung 19 of 39 rats developed malignant tumors, 16 of which were carcinomas." ... 

Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 1988 80 751-755. 

Tumor limited to the pancreas s 2 cm in greatest dimension Tumor limited to the pancreas > 2 cm in greatest dimension Tumor extends directly into any of the following duodenum, bile duct, peripancreatic tissue Tumor extends directly into any of the following stomach, spleen, colon, adjacent large vessels... 

Tumor invades the subepithelial connective tissue Tumor invades the fibromuscular layer Tumor invades the perifibromuscular connective tissue Tumor invades adjacent structures liver, pancreas, duodenum, gallbladder, colon, stomach... 

Tumors of the kidneys, spleen, and pancreas have also been reported (Christensen et al. 1983 Guimaraes et al. 1955 Kauziaric et al. 1987 Levy et al. 1986 Mori et al. 1979 Van Kaick et al. 

Obstructive jaundice, as the name implies, is caused by blockage of the bile duct by a gallstone or a tumor (usually of the head of the pancreas). 

Streptozocin produces remission in 50 to 60% of patients with islet cell carcinomas of the pancreas. It is also useful in malignant carcinoid tumors. 

Fluorouracil is used in several combination regimens in the treatment of breast cancer. It also has palliative activity in gastrointestinal adenocarcinomas, including those originating in the stomach, pancreas, liver, colon, and rectum. Other tumors in which some antitumor effects have been reported include carcinomas of the ovary, cervix, oropharynx, bladder, and prostate. Topical 5-fluorouracil cream has been useful in the treatment of premalignant keratoses of the skin and superficial basal cell carcinomas, but it should not be used in invasive skin cancer. 

---