Brenner tumor

Gastrointestinal, pancreas, biliary, lung, transitional cell, sweat glands, mucosal squamous cell, mucinous carcinomas of female GU tract, medullary carcinoma of thyroid Breast, squamous cell, endometrioid, Brenner tumor Renal cell, hepatocellular, prostate, follicular thyroid, adrenal cortical, serous carcinomas of female GU tract, embryonal, yolk sac, mesothelioma... 

Brenner tumors of the ovary have an immunoprofile similar to urothelial tumors. 

Ogawa K, Johansson SL, Gohen SM. Immunohistochemical analysis of utoplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Am JPathol. 1999 155 1047. 

FIGURE 18.31 The epithelial elements in Brenner tumors are CK7 positive. They are also reported to stain for markers of urothelial differentiation such as uroplakin, p63, and thrombomodulin (where there is cytoplasmic and membrane staining), as shown here. 

Recent studies show similarities between the immuno-phenotypes of Brenner tumor epithelium and urothe-lium, suggesting that the transitional cell appearance of the epithelium in Brenner tumors represents true... 

Ordonez NG, Mackay B. Brenner tumor of the ovary A comparative immunohistochemical and ultrastructural study with transitional cell carcinoma of the bladder. Ultrastruct Pathol. 2000 24 157-167. 

Riedel I, Czernobilsky B, Lifschitz-Mercer B, et al. Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation Immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins. Virchows Arch Int J Pathol. 2001 438 181-191. 

Clear cell carcinoma -Brenner tumor and ovarian transitional cell carcinoma ... 

Tumors of the thecoma-fihroma subgroup are characterized hy fibrous components and include fibroma, fibrothecoma, cystadenofibroma, and Brenner tumors. They account for the vast majority of the sex cord stromal tumors and are benign, except for Brenner tumors, which may rarely be malignant. 

Brenner tumors present rare ovarian tumors that occur at a mean age of 50 years. Brenner tumors constitute l%-3% of ovarian tumors. They are mostly henign, with less than 2% demonstrating borderline or malignant transformation. They are typically small, solid, unilateral ovarian tumors, with 60% of these tumors found under 2 cm in size. Extensive calcification may he observed. The vast majority is discovered incidentally in pathologic specimen of the adnexa. Brenner tumors rarely produce estrogen, and then they may be associated with endometrial thickening [87]. If cystic components are found in Brenner tumors, they may be associated with cystadenomas [88]. Up to 20% of Brenner tumors are associated with mucinous cystadenomas or other epithelial neoplasm (Fig. 9.34). 

The typical finding of a Brenner tumors is a small solid tumor that displays very low SI on the T2-weighted images [87]. Dense amorphous calcifications in a small solid ovarian tumor is a typical CT finding. In one series of eight Brenner tumors, the... 

Either benign or malignant ovarian tumors may be associated with virilization. Virilization has been observed in patients with adrenal rest tumors, Leydig cell tumors, granulosa cell tumors, Brenner tumors, and arrhenoblastomas. In patients with hirsutism associated with amenorrhea and sterility, the androstene-... 

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