Islet cell carcinoma

Streptozocin produces remission in 50 to 60% of patients with islet cell carcinomas of the pancreas. It is also useful in malignant carcinoid tumors. 

Stimulates granulocyte and macrophage production after chemotherapy Islet cell pancreatic carcinoma, malignant carcinoid tumor Breast cancer... 

NT296 Pour, P. M., and A. Rivenson. induction of a mixed ductal-squamous-islet cell carcinoma in a rat treated with a tobacco-specific carcinogen. Am J Pathol 1989 134(3) 627-631. 

The answer is d. (Hardman, pp 1242-1243.) Streptozocin is an alkylating agent with the capacity to cross-link DNA, thereby inhibiting its synthesis. It is a nitrosourea-like antibiotic that contains a glucosamine moiety that allows it to be selectively taken up by the p cells of the islets of Langerhans. Consequently, it can be useful in treating metastatic islet cell carcinoma. 

Pancreatic islet cell carcinoma Surgery, combination chemotherapy... 

Lomustine (CCNU) is used to treat lymphomas and some solid tumors, particularly brain tumors, often in combination with procarbazine and vincristine (2). Nimustine (ACNU) is used to treat mahgnant glioma (3). Streptozocin (streptozotocin) is produced by Streptomyces achromogenes. It is used to treat metastatic islet cell carcinoma of the pancreas, but because of its high nephrotoxic and emetogenic potential should be reserved for patients with symptomatic or progressive disease. 

Streptozocin (streptozotocin) is produced by Streptomyces achromogenes. It is used to treat metastatic islet cell carcinoma of the pancreas, but because of its high nephrotoxic and emetogenic potential it should be reserved for patients with symptomatic or progressive disease. 

Broder LE,and Carter SK. Pancreatic islet cell carcinoma, ii Results of therapy with streptozotocin in 52 patients. Ann intern Med, 79 108-118,1973... 

Myerowitz RL, Sartiano GP, and Cavallo T. Nephrotoxic and cytoproliferative effects of streptozotocin. Report of a patient with multiple hormone-secreting Islet cell carcinoma. Cancer, 38 1550-1555,1976... 

REUBI, J.C., et al., Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas, Cancer Res, 50 (1990)5969-5977. 

Poorly differentiated endocrine neoplasms, depending on the site of origin, may produce characteristic peptide hormones. The group of poorly differentiated neuroendocrine tumors and their hormone production include islet cell tumors (insulin, glucagon, somatostatin, gastrin), pulmonary small cell carcinoma (bombesin in 45% of cases), and medullary thyroid carcinoma (calcitonin). 

Streptozotocin is a naturally occurring nitrosourea useful for the treatment of advanced islet cell carcinomas and carcinoid tumors [107]. 

Streptozotocin is unique both in origin and pharmacology. It is an antibiotic obtained from Streptomyces achromogenes and contains a glucosamine component in its structure, which may contribute to its tendency to be taken up into the P-cells of the islets of Langerhans of the pancreas. Where it was initially used to induce diabetes in experimental animals, it is now used to treat pancreatic islet cell carcinoma, resulting in about a 50% response rate, but few survivors past 1 year. 

Streptozocin, a naturally occurring nitrosourea antibiotic derived from Streptomyces acromogenes (500 mg/m2 fV for 5 consecutive days q 4 to 6 weeks until maximum benefit or toxicity is observed), is indicated in metastatic islet cell carcinoma of the pancreas. Streptozocin is nephrotoxic causing azotemia, glycosuria and renal tubular acidosis, and mild proteinuria. 

Because of its unique toxicity against beta cells of the pancreas, streptozotocin is used almost exclusively to treat islet cell carcinoma of the pancreas. Its use is rare. 

Diazoxide is administered orally in the management of hypoglycemia caused by hyperinsulinism associated with inoperable islet cell adenoma or carcinoma or extrapancreatic malignancy in adults. 

CD57 (leu 7) Neuroendocrine tumors T-cell lymphoma and pre T-ALL, chordoma, MPNST, germ cell tumors, papillary thyroid carcinoma, thymic carcinoma, germ cell tumors, synovial sarcoma, carcinoid tumors, schwannoma, mesothelioma, astrocytoma and glioblastoma NK-cells, Schwann cells, gastric chief cells, adrenal medulla, pancreatic islets, renal tubular epithelium, epithelial cells of thymic cortex, retina, oligodendrocytes... 

Neuroendocrine tumors pituitary adenomas, medullary thyroid carcinoma, pheochromocytoma, islet cell... 

Synaptophysin Neuroendocrine tumors pituitary adenomas, medullary thyroid carcinoma, pheochromocytoma, islet cell tumors, small cell carcinoma, carcinoid and neuroendocrine Medulloblastoma, retinoblastoma, neurocytoma, ependymoma, neuroblastoma, adrenocortical tumors. Merkel cell tumors Neuronal and neuroendocrine cells, carotid body cells, adrenal cortex and medulla... 

Von Hippel-Lindau disease (VHL) is an autosomal dominant condition secondary to an alteration in a tumor suppressor gene on chromosome 3. It has incomplete penetrance and is characterized by hemangioblastomas in the retina, CNS, renal cell carcinoma, endolymphatic sac tumors, pheochro-mocytomas, papillary cystadenoma of the epididymis, angiomas of the liver and kidney, cysts of the liver, kidney and epididymis, and pulmonary arteriovenous shunts (Fig. 4.18a-c). In the pancreas, VHL may have multiple presentations, the most common being the presence of multiple small pancreatic cysts with calcifications in 40% of cases. Serous cystad-enomas, solid nonfunctional islet cell tumors, and adenocarcinoma are less common (Richard et al. 2004). 

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