Pancreas carcinoma

Moller A, Malerczyk C, Volker U, Stoppler H, Maser E. Monitoring daunor-ubicin-induced alterations in protein expression in pancreas carcinoma cells by two-dimensional gel electrophoresis. Proteomics 2002 2 697-705. 

Schuhmacher J, Zhang H, Doll J, et al. (2005) GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nude mice with a (68) Ga-labeled Bombesin (6-14) analog. J Nucl Med 46,691-699. 

Table 3.3 First candidate molecular markers for PanlN-2 grade pancreas carcinoma analyzing 1000 microdissected cells.

Borg A, Sandberg T, Nilsson K, et al. High frequency of multiple melanomas and breast and pancreas carcinomas in CDK-N2A mutation-positive melanoma families. J Natl Cancer Inst. 2000 92 1260-1266. 

CD7 T-ALL and T-cell lymphomas CML, ALL, cholangiocellular carcinoma, pancreas carcinoma Thymocytes, mature T-cells and NK cells, pre-B cells, monocytes, early myeloid cells... 

The liver is the most frequent site of metastases as a result of the portal circulation and up to 60%-80% of patients with a history of colorectal carcinoma, pancreas carcinoma, breast cancer or other tumor types will develop metastases within the liver during the follow-up period [1]. There is no doubt that surgical resection of these metastases is the only potential curative option for these patients and is therefore considered as gold standard. However, due to anatomic or technical reasons or simple inoperability. 

Morphine can be detected in the skin of toads (Fig. 5.51), [86] rats and rabbits, as well as in the hypothalamus and kidneys of cattle and the cerebrospinal fluid of humans. Also breast mUk and cow s mUk contain 200-500 ng/litre of morphine. It is therefore assumed, that aU species employ the same biosynthetic route as the opium poppy. [87] Meinhart H. Zenk (1933-2011) was able to prove that human neuroblastoma and pancreas-carcinoma cells can produce [ 0]-labelled morphine in the presence of 02. [88]... 

Kaji M, Ishikura H, Kishimoto T, Omi M, Ishizu A, Kimura C, et al (1995) E-selectin expression induced by pancreas-carcinoma-derived interleukin-1 alpha results in enhanced adhesion of pancreas carcinoma cells to endothelial cells. Int J Cancer 60 712-717... 

Pharmacokinetic Principles 33 Dose-Response Relationship 34 Intraperitoneal Application 34 Intra-arterial Application 34 Isolated Perfusion Techniques Application Techniques 35 Intracavitary Application 35 Intra-arterial Infusion 36 Regional Perfusion Techniques Stop-Flow Perfusions 36 Isolated Extremity Perfusion (ILP) 37 Hyperthermic Peritoneal Perfusion (HIPEC) 38 Clinical Indications 38 Pancreas Carcinoma 38 Bronchial Carcinoma 39 Extremity Sarcoma 40 Peritoneum 41 Surgical Technique 41 Rationale 42 Clinical Results 43 References 44 Further Reading 45... 

In view of the context-dependent involvement of hGal-l in disease, as in pancreas carcinoma progression or in glioblastoma invasion these data represent a useful hint for the design of biopharmaceuticals. 

Most kidney transplant procedures are heterotopic, where the kidney is implanted above the pelvic bone and attached to the patient s iliac artery and vein. The ureter of the transplant kidney is attached directly to the recipient s bladder or native ureter. The native kidneys usually are not removed, and data have shown that under most circumstances, removal of the native kidneys does not influence patient survival and allograft survival. Special circumstances, however, such as renal cell carcinoma and PCKD, may necessitate native kidney removal.1,3 There were 16,477 (9914 deceased donors, 6563 living donors) kidney transplants and 903 simultaneous kidney-pancreas procedures done in 2005.3... 

Eugene Dowdle You know, there was a study showing that carcinoma of the pancreas was associated with drinking coffee. A very strong correlation. Then it turned out that people who drink lots of coffee smoke while they re... 

Gastrointestinal, pancreas, biliary, lung, transitional cell, sweat glands, mucosal squamous cell, mucinous carcinomas of female GU tract, medullary carcinoma of thyroid Breast, squamous cell, endometrioid, Brenner tumor Renal cell, hepatocellular, prostate, follicular thyroid, adrenal cortical, serous carcinomas of female GU tract, embryonal, yolk sac, mesothelioma... 

In rats, AAF had no demonstrable acute toxicity in quantities up to 50mg/kg subcutaneously and 1 g/% gastrically however, AAF was very toxic when administered in the diet." Incorporation of 0.031% AAF or higher for at least 95 days led to epithelial hyperplasia of the bladder, renal pelvis, liver, pancreas, and lung 19 of 39 rats developed malignant tumors, 16 of which were carcinomas." ... 

Fluorouracil is used to treat carcinomas of the head, neck, colon, rectum, breast, stomach, bladder, pancreas, and for actinic and solar creatitis. Synonyms of this drug are efQu-derm, fludix, fluoroblastin, arumel, benton, lifril, and others. 

It is also alkylating agent and inhibits DNA synthesis. It is administered intravenously in combinations with other chemotherapeutic drugs for treating carcinomas of the pancreas, breast, lungs, prostate, head, neck, and so on. Synonyms of this drug are ametycin and others. 

Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 1988 80 751-755. 

Okami J, Yamamoto H, Fujiwara Y, et al. Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res 1999 5 2018-2024. 

Gemcitabine is intracellularly activated by nucleoside kinases to diphosphate and triphosphate nucleosides. Gemcitabine diphosphate inhibits DNA synthesis by inhibiting ribonucleotide reductase while gemcitabine triphosphate competes with deoxycytidine triphosphate for incorporation into DNA. Gemcitabine is used for the treatment of non-small cell lung carcinoma and of adenocarcinoma of the pancreas. It has to be administred intravenously and is eliminated by metabolism with an elimination half-life of approximately 50 minutes. Its spectrum of adverse effects is comparable to that of 5-FU. 

Streptozocin produces remission in 50 to 60% of patients with islet cell carcinomas of the pancreas. It is also useful in malignant carcinoid tumors. 

Fluorouracil is used in several combination regimens in the treatment of breast cancer. It also has palliative activity in gastrointestinal adenocarcinomas, including those originating in the stomach, pancreas, liver, colon, and rectum. Other tumors in which some antitumor effects have been reported include carcinomas of the ovary, cervix, oropharynx, bladder, and prostate. Topical 5-fluorouracil cream has been useful in the treatment of premalignant keratoses of the skin and superficial basal cell carcinomas, but it should not be used in invasive skin cancer. 

Mitomycin has limited palhative effects in carcinomas of the stomach, pancreas, colon, breast, and cervix. 

Benzyl acetate was tested for carcinogenicity by gavage in one experiment in mice of both sexes and in one experiment in rats of both sexes. In the study in mice, increased incidences of liver adenomas and of combined liver adenomas and carcinomas were observed in animals of each sex the incidence of carcinomas of the liver alone was not significantly increased in animals of either sex. An increased incidence of forestomach tumours was observed in mice of each sex. An increased incidence of acinar-cell adenomas of the pancreas was observed in male rats (lARC, 1986). 

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