Regional perfusion

T. Salmonson, and G. Amidon. The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum experience from a regional perfusion technique., Eur. J. Pharm. Sci. 2002, 15, 271-277... 

Abe S, Tokizaki T, Miki Y, Tateishi A, Ogawa K, Nakano H, Matsushita T (2005) Hyperthermic isolated regional perfusion with CDDP for bone and soft-tissue sarcoma of the lower limb pharmacokinetics, thermal dose, toxicity, and feasibility. Cancer Chemotherapy and Pharmacology 56 55-62. 

Tannergren C, Knutson T, Knutson L and Lennernas H (2003) The Effect of Ketoconazole on the In Vivo Intestinal Permeability of Fexofenadine Using a Regional Perfusion Technique. BrJ Clin Pharmacol 55 pp 182-190. 

Flow through moderately severe coronary artery stenosis is commonly normal at rest but becomes inadequate for the increased metabolic requirements and blood flow during stress. Coronary blood flow normally increases to four times resting baseline flow rates after coronary artery vasodilators such as dipyridamole and adenosine. A stenosis restricts maximal blood flow capacity compared to normal coronary arteries, thereby causing a disparity in regional perfusion of areas supplied by a stenotic artery compared to normal coronary arteries. This disparity manifests as a relative perfusion defect during stress, corresponding to the ischemic myocardial territory supplied by a stenotic artery. Furthermore, the quantitative severity of the relative perfusion defect is proportional to the severity of the stenosis under conditions of maximal coronary flow after dipyridamole or adenosine stress [24]. 

As indicated in Table 2.1, drugs may be injected into veins, muscles, subcutaneous tissue, arteries, or into the subarachnoid space of the spinal canal (intrathecal). For obvious reasons, intraarterial and intrathecal injections are reserved for specialized drug administration requirements, such as regional perfusion of a tumor with a toxic drug or induction of spinal anesthesia, respectively. Therefore, the more routine injection routes are intravenous (IV), intramuscular (IM), and subcutaneous (SC). Because these three modalities involve skin puncture, they carry the risks of infection, pain, and local irritation. 

Noone, R.B., Jr. Mythen, M.G. Vaslef, S.N. Effect of aa-cross-linked hemoglobin and pyridoxalated hemoglobin polyoxyethylene conjugate solutions on gastrointestinal regional perfusion in hemorrhagic shock. J. Trauma 1998, 45 (3), 457-469. 

Regional perfusion was first assessed in the equine literature as a technique for achieving high levels of antimicrobial agents in the carpus (Whitehair et al 1992). The basic principle involves the saturation of tissues with volume-diluted antimicrobial agent. The antimicrobial agent is... 

Tannergreen, C., Knutson. T. Knutson, L., and Lennernas, H. (2003) The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. British Journal of Clinical Pharmacology, 55, 182-190. 

Determination of right-to-left shunts Arterial injection Regional perfusion in other organs... 

Diagnosis of reduced regional perfusion and myocardial infarction ... 

Ncurovue Brislol-Myers Squibb 2.S Regional perfusion... 

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