P-388-Lymphocytic leukemia

Biological Activity. The maytansinoids possess antitumor activity, particulady against P 388 lymphocytic leukemia, B 16 melanocarcinoma, and Lewis lung carcinoma. A number of semisynthetic esters of maytansinol have been prepared and exhibit good antileukemic activity (52,255). The maytansides lack antitumor activity, indicating that the ester at C-3 is a requirement for activity (50,52). The carbinolamide also appears to be necessary for... 

The synthesis of the triazinotriazines 519 was achieved (87MI5) by reaction of 3-hydrazino-5,6-diphenyl[l,2,4]triazine 518 with 4-substituted phenacyl halides. These triazinotriazines were screened against P-388 lymphocytic leukemia in mice and were inactive. 

Compounds 594 were screened against P-388 lymphocytic leukemia in mice and were inactive. 

Pancratistatin (15) (Figure 7.4) was isolated by Pettit and co-workers from the roots of Pancratium littorale, which exhibits anticancer activity against murine P-5076 ovarian sarcoma and P-388 lymphocytic leukemia [10]. Rigby and coworkers performed photocycHzation as a key step in the total synthesis of 15,... 

Morinda parvifolia Bartling Xiao Ye Yang Jiao Teng (root) Methanolic, morindaparvin-a, alizarin-l-methyl ether.50 Against p-388 lymphocytic leukemia growth (in vivo), cytotoxic, antileukemic. 

A new bromopyrrole alkaloid 15 along with racemic 16 was isolated from the Japanese marine sponge Homaxinellct sp. They exhibit weak cytotoxic activity against P-388 lymphocytic leukemia cells with ED50 values of 21.5 pg/ml and 30 pg/ml, respectively [34]. 

The chlorocyclohexene derivative from the marine microorganism Periconia byssoides, pericosine A (170), is 33 times more cytotoxic in the P-388 lymphocytic leukemia test (IC50 0.12 pg/ml) than the corresponding methoxy compound [131]. 

Ansamycin antibiotics are probably the most complex organic compounds produced by the genus Streptomyces. In addition to the antibacterial, they also exhibit antiviral effects. Ansamitocin P-3 shows a potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. The compound exhibits a significant activity against P-388 lymphocytic leukemia in mice and both 9PS (murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) in cell culture systems. [38]. 

Daphneticin (12), isolated from Daphne tangutica, showed cytotoxic activity against Walker carcinosarcoma ascites cells (68) but was inactive against KB cells (68). In vitro studies showed cleomiscosin A (9), isolated from the chloroform extract of Brucea javanica, to be active against the murine P-388 lymphocytic leukemia cell line (EDsq = 0.4 pg ml ), but inactive against the KB test system (57). Luyengi et al. reported the lack of activity of the same compound when evaluated against HL-60 human promyelocytic leukemia cells (59). 

Cleomiscosin A (9) Cytotoxic against P-388 (lymphocytic leukemia) cell line (57)... 

See also Chapter 7, Section 4.1. An investigation details the isolation of (Z)-l, 8-pentadecadiene from E. angustifolia and E. pallida. This root oil constituent has inhibitory effects against Walker carcinosarcoma 256 and P-388 lymphocytic leukemia in the mouse and rat, respectively (18). 

The 6-substituted cyano bipyridine has been generated in 95% yield from bipyridine A-oxide by reaction with trimethylsilylcyanide and dimethylcarbamylchloride.76 This is an improvement on an earlier method that generated 6-cyano bipyridine from the A-oxide in 62% yield using potassium cyanide and benzoyl chloride.77 This ligand has been used in electrochemical studies of rhenium complexes with sterically hindered bipyridine derivatives, as well as a precursor in the synthesis of 6-carbothioamide-bpy, which showed antitumor activity against P-388 lymphocytic leukemia in mice.77... 

Cedronolactone B (29) and cedronolactone C (30), isolated from wood of Simaba cedron were shown, exhibited in vitro cytotoxicity (IC50 6.5 and 49 pg/mL) against P-388 lymphocytic leukemia cells [19]. 

Yadanziosides F (93), I (94), J (95), and L (96) were demonstrated to have in vivo antileukemic activity against the murine P-388 lymphocytic leukemia. 

Bruceanol C (66) demonstrated potent cytotoxicity against human KB, A-549 lung carcinoma, and HCT-8 colon tumor as well as murine P-388 lymphocytic leukemia with ED o values of < 0.04, 0.48, <0.40, and 0.56 pg/mL, respectively [36],... 

Simalikalactone D (282) [130] the major constituent of Quassia africatia Baill. have occupied the attention of synthetic chemists for well over years, in part because these cytotoxic substance exhibit potent activity in vivo against the P-388 lymphocytic leukemia in mice (PS). 

Communesins A (70) and B (71) were originally isolated from the mycelia of a strain of Penicillium sp. adhering to the marine alga, Enteromorpha intestinalis, and reported to exhibit cytotoxic activity in the P-388 lymphocytic leukemia test system in cell cultures [49], The ED50 values for 70 and 71 are reported to be 3.5 and 0.45 pg/ml, respectively, in the test system. 

Table XIV Antitumor Activities on P-388 Lymphocytic Leukemia and Toxicities of Ether Derivatives of RA-V...

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