Periconia byssoides

The chlorocyclohexene derivative from the marine microorganism Periconia byssoides, pericosine A (170), is 33 times more cytotoxic in the P-388 lymphocytic leukemia test (IC50 0.12 pg/ml) than the corresponding methoxy compound [131]. 

Peribysins C and D were initially reported in 2004 as diastereomers that functioned as potent cell adhesion inhibitors from the fungus Periconia byssoides separated from the sea hare Aplysia kurodai These compounds... 

Pericosines A (216) and B have been isolated from a strain of Periconia byssoides, originally separated from the sea hare Aplysia... 

Yamada T, Iritani M, Ohishi H, Tanaka K, Minoura K, Doi M, Numata A. Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities. Org. Biomol. Chem. 2007 5(24) 3979-3986. 

Here again, there has been little work on the metabolites of fungi associated with mollusks. Isolated from the sea hare, Aplysia kurodai, the fungus Periconia byssoides produces in culture two cytotoxic derivatives, pericosines A and H, and four trilactones, macrosphelides E-H, which are devoid of activity (Numata et al, 1997b). The cytotoxicity of pericosines A and B on P-388 is notable with... 

Subsequently, through culture of the same fungus, Periconia byssoides, collected from the same mollusk, Aplysia kurodai, the same team isolated a series of irregular sesquiterpenes, peribysins A-D, which are inhibitors of cell adhesion of HL-60 (human leukemia) on HUVECs (human umbilical vein endothelial cells) and could be useful for the treatment of metastasis. Peribysin D is 380 times more active than herbimycin A, which is used as a standard (Yamada et al., 2004). 

Macrosphelides A (75) and B (76), isolated from Mucrosphueropsis sp. FO-5050 and Periconia byssoides, have antitumoral properties. For their synthesis, several RCM conditions were used, but 1 equiv. of [Ru]-II catalyst and long reaction time were necessary to obtain the cyclized product in reasonable yields (60-65%, Scheme 5.17). The authors pointed out that the addition of a Lewis acid under catalytic conditions was ineffective [41]. 

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