Organic anion transporting

Cellular defense mechanisms against toxins (A multistep mechanism for elimination of toxic metabolites and xenobiotics. It involves various transport, oxidation, and conjugation steps.) are usually divided into several steps as it is visualized on Fig. 3. Organic anion transporting proteins (OATPs) are responsible for the cellular uptake of endogenous compounds and... [Pg.750]

MDR-ABC Transporters. Figure 3 Detoxification cellular mechanisms. X, toxic compound X-OH, oxidized toxic compound GS-X, conjugated toxic compound OATP, organic anion transporting proteins CYPs, cytochromes GSH, glutathion UDPGIcUA, Uridine 5-diphosphoglucuronic acid PAPs, 3-phosphoadenylylsulfate. [Pg.751]

Sasaki M, Suzuki H, Aoki J, Ito K, Meier PJ and Sugiyama Y. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Mol Pharmacol 2004 66 450-9. [Pg.510]

Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 2000 273 251-60. [Pg.512]

Chang C, Pang KS, Swaan PW, Ekins S. Comparative pharmacophore modeling of organic anion transporting polypeptides a meta-analysis of rat Oatplal and human OATPIBI. J Pharmacol Exp Ther 2005 314 533-41. [Pg.512]

Yarim M, Moro S, Huber R, Meier PJ, Kaseda C, Kashima T, et al. Application of QSAR analysis to organic anion transporting polypeptide la5 (Oatpla5) substrates. Bioorg Med Chem 2005 13 463-71. [Pg.512]

Heijn, M., Oude Elferink, R. and Jansen, P. (1992). ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles. Am. J. Physiol. 262, 104-110. [Pg.71]

C. C. Paulusma, R. P. Oude Elferink et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA, J. Clin. Invest. 1998, 101, 1310-1319... [Pg.88]

In cell lines, the organic anion transporters (OAT and OATP) have been identified and cloned into cells of kidney origin such as LLC-PK1, MDCK, HK-2, and Caco-2 [129]. The most well-known uptake transporters, which transport the substrate over the membrane into the organism are the amino acid- [35, 42, 139] and oligopeptide-carriers (PepTl and PepT2) [139-142]. These two transporter families are abundantly expressed in the small intestine of most animals, and can therefore be involved in the absorption process of pharmaceutical drugs. The PepTl is expressed in the cell lines Caco-2 and HT-29 [140-142]. [Pg.114]

Organic anion transporters play important roles in the elimination of a variety of endogenous anionic substances, xenobiotics, and their metabolites from the body... [Pg.259]

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. [Pg.260]

Organic anion transporters OAT1 PAH, methotrexate, p-lactam antibiotics,... [Pg.261]

Organic anion transporting OATP1/2 bromosulfophthalein (BSP), pravastatin,... [Pg.261]

Endou. The multispecific organic anion transporter (OAT) family. [Pg.279]

Sweet, D. H., N. A. Wolfe, and J. B. Pritchard. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J. Biol. Chem. 1997, 272, 30088-30095. [Pg.279]

Sekine, T., et al. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEES Lett. 1998, 429, 179-182. [Pg.279]

Kusuhara, H., et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 1999, 274, 13675-13680. [Pg.279]

Jacquemin, E., et al. Expression cloning of a rat liver Na(+)-indepen-dent organic anion transporter. Proc. Natl. Acad. Sci. U. S. A 1994, 93, 133-137. [Pg.279]

Kullak-Ublick, G. A., etal. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995, 109, 1274—1282. [Pg.279]

Konig, J., et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. 2000, 278, G156-G164. [Pg.279]

Abe, T., et al. LST-2, a human liver-spedfic organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001, 120, 1689—1699. [Pg.279]

Konig, J., et al. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 2000, 275, 23161-23168. [Pg.279]

Ismair, M. G., et al. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001, 121, 1185-1190. [Pg.279]

Pizzagalli, F., et al. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol. Endocrinol. 2002, 36, 2283-2296. [Pg.279]

St-Pierre, M. V., etal. Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J. Clin. Endocrinol. Metab. 2002, 87, 1856-1863. [Pg.279]

Abu-Zahra, T. N., et al. Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab. Dispos. 2000, 28, 801-806. [Pg.280]

Ishizuka, H., et al. Transport of temocaprilat into rat hepatocytes role of organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 1998, 287, 37-42. [Pg.280]

Reichel, C., et al. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 1999, 117, 688-695. [Pg.280]

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