Organic Anion Transporter Polypeptides

Sasaki M, Suzuki H, Aoki J, Ito K, Meier PJ and Sugiyama Y. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Mol Pharmacol 2004 66 450-9. [Pg.510]

Chang C, Pang KS, Swaan PW, Ekins S. Comparative pharmacophore modeling of organic anion transporting polypeptides a meta-analysis of rat Oatplal and human OATPIBI. J Pharmacol Exp Ther 2005 314 533-41. [Pg.512]

Yarim M, Moro S, Huber R, Meier PJ, Kaseda C, Kashima T, et al. Application of QSAR analysis to organic anion transporting polypeptide la5 (Oatpla5) substrates. Bioorg Med Chem 2005 13 463-71. [Pg.512]

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. [Pg.260]

Kullak-Ublick, G. A., etal. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995, 109, 1274—1282. [Pg.279]

Konig, J., et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. 2000, 278, G156-G164. [Pg.279]

Konig, J., et al. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 2000, 275, 23161-23168. [Pg.279]

Ismair, M. G., et al. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001, 121, 1185-1190. [Pg.279]

Pizzagalli, F., et al. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol. Endocrinol. 2002, 36, 2283-2296. [Pg.279]

St-Pierre, M. V., etal. Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J. Clin. Endocrinol. Metab. 2002, 87, 1856-1863. [Pg.279]

Abu-Zahra, T. N., et al. Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab. Dispos. 2000, 28, 801-806. [Pg.280]

Ishizuka, H., et al. Transport of temocaprilat into rat hepatocytes role of organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 1998, 287, 37-42. [Pg.280]

Reichel, C., et al. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 1999, 117, 688-695. [Pg.280]

Isern, J., et al. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatpl) in the kidney. Biochim. Biophys. Acta 2001, 1518, 73-78. [Pg.280]

T. E. Schmid. Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatpl) and mapping of the gene to chromosome X. Biochem. [Pg.280]

P. J., Hagenbuch, B., Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatpl, Oatp2 and Oatp3, Pfliigers Arch. 2001, 443, 188-195. [Pg.303]

R., Pizzagalli, F., Fattinger, K., Meier, P. J., Hagenbuch, B., Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver, Gastroenterology 2001, 120, 525-533. [Pg.303]

Tamai, I., Nozawa, T., Koshida, M., Nezu, J., Sai, Y., Tsuji, A., Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C, Pharm. Res. 2001, 18, 1262-1269. [Pg.304]

In addition to PepTl, there is a related renal transporter, PepT2. There are also a series of other uptake transporters (organic anion transporting polypeptides, organic anion transporters, organic cation transporters), which are expressed primarily in the liver and other tissues but are not known to affect oral bioavailability. [Pg.336]

Organic Anion Transporting Polypeptide Family (OATP)... [Pg.180]

Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ. Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 2000 294(l) 73-79. [Pg.201]

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