Organic anion transporting polypeptide OATP transporters

Kim RB. Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur J Clin Invest 2003 33(suppl 2) 1-5. 

Troglitazone sulfate (Ml, the main metabolite) undergoes biliary excretion and accounts for up to 85% of the dose in humans (Loi et al. 1999). In patients with hepatic impairment, troglitazone sulfate was found to accumulate about fourfold in plasma with a threefold increased half-life (Ott et al. 1998 Loi et al. 1999). This metabolite also inhibited the canalicular bile salt export pump (Bsep), organic anion transporting polypeptide (OATP) transporters as well as drug transporters, suggesting it contributes to the hepatotoxicity. 

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. 

St-Pierre, M. V., etal. Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J. Clin. Endocrinol. Metab. 2002, 87, 1856-1863. 

R., Pizzagalli, F., Fattinger, K., Meier, P. J., Hagenbuch, B., Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver, Gastroenterology 2001, 120, 525-533. 

Tamai, I., Nozawa, T., Koshida, M., Nezu, J., Sai, Y., Tsuji, A., Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C, Pharm. Res. 2001, 18, 1262-1269. 

Organic Anion Transporting Polypeptide Family (OATP)... 

Pizzagalli F, Hagenbuch B, Bottom-ley KM, Meier PJ. Identification of a new human organic anion transporting polypeptide OATP-F. GenBank Accession No AF260704 2001. 

Hagenbuch, B. and Meier, P.J. (2004) Organic anion transporting polypeptides ofthe OATP/SLC21 family phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. 

Campbell, S.D., de Morais, S.M. and Xu, J.J. (2004) Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia. Chemico-Biological Interactions, 150, 179-187. 

Figure 14.5 Schematic diagram of the magnetic isolation method for rat retinal vascular endothelial cells (RVEC) (A) and the transcript level of organic anion-transporting polypeptides (Oatps) in RVEC (B). A Endothelial cells (RVEC) EC, Nonendothe-lial cells (Non-RVEC) Non-EC. B Not detected N.D. Data taken from Journal of Neurochemistry, 91, Tomi and Hosoya, Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. 1244-1248, 2004, with permission from Blackwell Publishing.

Immunohistochemical study ND not determined GLUT1 facilitative glucose transporter MCT1 monocarboxylate transporter CRT creatine transporter LAT1 L-type amino acid transporter TAUT taurine transporter ENT equilibrative nucleoside transporter Oatp organic anion-transporting polypeptide PAH p-aminohippuric acid RUI retinal uptake index TR-iBRB rat retinal capillary endothelial cells. 

D. Kobayashi, T. Nozawa, K. Imai, J. Nezu, A. Tsuji, and I. Tamai. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 306 703-708 (2003). 

OATP/oatp Organic anion transporting polypeptide (protein / nucleic acid)... 

---