Organic anion transporter renal

Race, J. E., et al. Molecular cloning and characterization of two novel human renal organic anion transporters (hOATl and hOAT3). Biochem. Biophys. Res. Commun. 1999, 255, 508-514. 

In addition to PepTl, there is a related renal transporter, PepT2. There are also a series of other uptake transporters (organic anion transporting polypeptides, organic anion transporters, organic cation transporters), which are expressed primarily in the liver and other tissues but are not known to affect oral bioavailability. 

Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 1999 56(3) 570-580. 

There have been several studies that underscore the importance of unbound concentration in cell-based studies of receptor function. In a model study of the effect of plasma protein binding on the renal transport of organic anions using the expression of various organic anion transporters (OATPs) in Xenopus oocytes, the transport of ochratoxin A, methotrexate, and estrone sulfate was found to be strongly inhibited by the addition of human serum albumin to the culture medium [16]. Similarly, the addition of oq-acid glycoprotein was found to reverse the blockade of sodium-ion current by cocaine in a preparation of cardiac myocytes [17]. 

Dantzler, W. H. (1996). Comparative aspects of renal organic anion transport, Cell. Physiol. Biochem., 6, 28-38. 

Y. Sakurai, H. Motohashi, H. Ueo, S. Masuda, H. Saito, M. Okuda, N. Mori, M. Matsuura, T. Doi, A. Fukatsu, O. Ogawa, and K. Inui. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res 21 61-67 (2004). 

Wolff, N.A., Werner, A., Burkhardt, S. and Burckhardt, G. Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 417 287-291, 1997. 

Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh E, Suzuki M, Tokui T, Unno M, Shimasagawa T, Matsuno S, Ito S, Abe T. Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol 2003 286 F1188-F1197. 

Bahn A, Ebbinghaus C, Ebbinghaus D, Ponimaskin EG, Fuzes L, Burckhardt G, Hagos Y. Expression studies and functional characterization of renal human organic anion transporter 1 isoforms. Drug Metab Dispos 2004 32 424-430. 

Ho ES, Lin DC, Mendel DB, Cihlar T. Citotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol 2000 11 383-393. 

Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Noshiro R, Takeda M, Kanai Y, Sophasan S, Endou H. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharmacol Sci 2004 94 297-304. 

Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto Y, Cha SH, Sekine T, Endou H. Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 2002 300 918-924. 

Probenecid has been reported to inhibit renal elimination of many drugs acyclovir (325,326), allopurinol (327), bumetanide (328), cephalosporins (329-334), cidofovir (335), ciprofloxacin (336), famotidine (337), fexofenadine (338), furosemide (339), and oseltamivir (Ro 64-0802) (340). Recent studies have elucidated that probenecid is a potent inhibitor of renal organic anion transporters (OAT1 and OAT3) with the Ki values lower than the unbound plasma concentration of probenecid, indicating the interaction with probenecid includes inhibition of the basolateral uptake process mediated by OAT1 and/or OAT3. 

Hasegawa M, Kusuhara H, Sugiyama D, et al. Functional involvement of rat organic anion transporter 3 (rOat3 Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 2002 300 746-753. 

Hasegawa M, Kusuhara H, Endou H, et al. Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 2003 305 1087-1097. 

Masuda S, Saito H, Nonoguchi H, et al. mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett 1997 407 127-131. 

Tojo A, Sekine T, Nakajima N, et al. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 1999 10 464-471. 

Jariyawat S, Sekine T, Takeda M, et al. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther 1999 290 672-677. 

Anzai N, Jutabha P, Enomoto A, et al. Functional characterization of rat organic anion transporter 5 (Slc22al9) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther 2005 315 534—544. 

Cihlar T, Ho ES. Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem 2000 283 49-55. 

Bossuyt X, Muller M, Meier PJ (1996) Multispecific amphi-pathic substrate transport by an organic anion transporter of human liver. J Hepatol 25(5) 733-738 Burckhardt G, Wolff NA (2000) Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 278(6) F853-F866... 

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