Organic anion transport cephalosporin nephrotoxicity

It has been suggested that mitochondrial injury may mediate, at least in part, the nephrotoxicity of some P-lactams [67]. Mitochondrial respiration with and uptake of succinate after exposure to toxic doses of cephaloridine, cephaloglycin, or imipenem [98] showed significant reduction of both functions. Cephalexin did not affect either the mitochondrial uptake or respiration with succinate. Depressed mitochondrial respiration secondary to acylation of the mitochondrial transporter for succinate appears to be implicated in renal toxicity caused by cephalosporins and carbapenems [98]. The organic anion fluorescein accumulates in mi-... 

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