Organic Anion Transporter Family OAT

Sekine T, Cha S, Kanai Y, Endou Ei. Molecular biology of multispecific organic anion transporter family (OAT family). Clin Exp Nephrol 1999 3 237-243. [Pg.67]

The organic anion transporters (human OATs, rodent oats) are classified within the SLC22A solute carrier family, and the transporting peptides (human OATPs, rodent... [Pg.276]

ABC, ATP-binding cassette transporter superfamily ASBT, apical sodium-dependent bile salt transporter BCRP, breast cancer resistance protein BSEP, bile salt export pump MDRl, multidrug resistance MRR multidrug resistance-related protein NTCP, sodium taurocholate cotransporting polypeptide OAT, organic anion transporter OCT, organic cation transporter SLC, solute-linked carrier transporter family SLCO, solute-linked carrier organic anion transporter family. [Pg.88]

In cell lines, the organic anion transporters (OAT and OATP) have been identified and cloned into cells of kidney origin such as LLC-PK1, MDCK, HK-2, and Caco-2 [129]. The most well-known uptake transporters, which transport the substrate over the membrane into the organism are the amino acid- [35, 42, 139] and oligopeptide-carriers (PepTl and PepT2) [139-142]. These two transporter families are abundantly expressed in the small intestine of most animals, and can therefore be involved in the absorption process of pharmaceutical drugs. The PepTl is expressed in the cell lines Caco-2 and HT-29 [140-142]. [Pg.114]

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. [Pg.260]

Endou. The multispecific organic anion transporter (OAT) family. [Pg.279]

In addition to OATP/Oatp family proteins, some of the organic anion transporter (OAT) family proteins may be responsible for hepatic uptake. Although many OAT family proteins are expressed in the kidney [36], human and rat OAT2 is also expressed in the liver [37, 38]. Human OAT2 transports p-amino-... [Pg.291]

Sekine T, Cha SH, Endou H. The multispecific organic anion transporter (OAT) family. Pfliigers Arch 2000 440(3) 337—350. [Pg.203]

One of the many families included in the MFS is the SLC (solute carrier) superfamiiy. The SLC superfamiiy represents approximately 300 genes in the human genome that encode for either facilitated transporters or secondary active symporters or antiporters. Members of the SLC superfamiiy transport various ionic and nonionic endogenous compounds and xenobiotics. The SLC22 family includes anion and cation transporters (Organic Anion Transporters, OATs Organic Cation Transporters, OCTs). [Pg.364]

Table 5. Organic anion transporter (OAT) and organic anion transporting polypeptide (OATP) families (from [34], with permission).

The drug uptake (SLC) family of transporter is the largest superfamily of transporters. This family includes 31 transporters from organic anion transporter polypeptides (OATPs), organic anion transporters (OATs), organic cation transporters (OCTs), peptide cotransporters (PEPTs), and sodium-bile acid cotransporter classes. Only OATP, OAT, OCT, and PEPT are primarily involved with the transport of drugs/xenobiotics. [Pg.16]