Organic Anion Transporter Family

The OAT4 was cloned from human kidney but is also expressed at appreciable levels in the placenta (54). In kidney, OAT4 is localized to the apical 

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Anzai, N., Kanai, Y., and Endou, H. Organic anion transporter family Current knowledge. J. Pharmacol. Sci. 100, 411 126, 2006. 

Miyazaki H, Sekine T, Endou H. The multispecific organic anion transporter family Properties and pharmacological significance. Trends Pharmacol Sci 2004 25 654-62. 

Sekine T, Cha S, Kanai Y, Endou Ei. Molecular biology of multispecific organic anion transporter family (OAT family). Clin Exp Nephrol 1999 3 237-243. 

SLCO Solute carrier organic anion transporter family ... 

SLC21 Organic Anion Transporter Family (OATP) 11... 

ABC, ATP-binding cassette transporter superfamily ASBT, apical sodium-dependent bile salt transporter BCRP, breast cancer resistance protein BSEP, bile salt export pump MDRl, multidrug resistance MRR multidrug resistance-related protein NTCP, sodium taurocholate cotransporting polypeptide OAT, organic anion transporter OCT, organic cation transporter SLC, solute-linked carrier transporter family SLCO, solute-linked carrier organic anion transporter family. 

Sweet DH, Bush KT, and Nigam SK (2001) The organic anion transporter family from physiology to ontogeny and the clinic. Am J Physiol 281 F197 F205. 

Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 2000 273 251-60. 

In cell lines, the organic anion transporters (OAT and OATP) have been identified and cloned into cells of kidney origin such as LLC-PK1, MDCK, HK-2, and Caco-2 [129]. The most well-known uptake transporters, which transport the substrate over the membrane into the organism are the amino acid- [35, 42, 139] and oligopeptide-carriers (PepTl and PepT2) [139-142]. These two transporter families are abundantly expressed in the small intestine of most animals, and can therefore be involved in the absorption process of pharmaceutical drugs. The PepTl is expressed in the cell lines Caco-2 and HT-29 [140-142]. 

Organic anion transporters can be divided into three major families organic anion transporters (OATs), organic anion transporting polypeptides (OATPs), and multidrug resistance associated proteins (MRPs) [201]. 

Endou. The multispecific organic anion transporter (OAT) family. 

Abe, T., et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-l.J. Biol. Chem. 1999, 274, 17159-17163. 

In addition to OATP/Oatp family proteins, some of the organic anion transporter (OAT) family proteins may be responsible for hepatic uptake. Although many OAT family proteins are expressed in the kidney [36], human and rat OAT2 is also expressed in the liver [37, 38]. Human OAT2 transports p-amino-... 

Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., Matsuno, S., Yawo, H., Identification of a novel gene family encoding human liver-specific organic anion transporter 1 ST-1, /. Biol. Chem. 1999, 274, 17159-17163. 

P. D., Erion, M. D., Isolation of a family of organic anion transporters from human liver and kidney,... 

Organic Anion Transporting Polypeptide Family (OATP)... 

Hagenbuch, B. and Meier, P.J. (2004) Organic anion transporting polypeptides ofthe OATP/SLC21 family phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. 

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