Organic anion transporter hepatic

Ismair, M. G., et al. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001, 121, 1185-1190. 

Cui, Y., et al. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6J. Biol. Chem. 2001, 276, 9626-9630. 

In addition to OATP/Oatp family proteins, some of the organic anion transporter (OAT) family proteins may be responsible for hepatic uptake. Although many OAT family proteins are expressed in the kidney [36], human and rat OAT2 is also expressed in the liver [37, 38]. Human OAT2 transports p-amino-... 

M. Iwai, H. Suzuki, I. Ieiri, K. Otsubo, and Y. Sugiyama. Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C). Pharmacogenetics 14 749-757 (2004). 

Nozawa, T., Minami, H., Sugiura, S., Tsuji, A., and Tamai, 1. (2005) Role of organic anion transporter OATPIBI (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin in vitro evidence and effect of single nucleotide polymorphisms. Drug Metab. Dispos. 33, 434—439. 

Morita N, Kusuhara H, Nozaki Y, et al. Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen. Drug Metab Dispos 2005 33 1151-1157. 

Rausch-Derra LC, Hartley DP, Meier PJ, et al. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology 2001 33 1469-1478. 

Treiber A, Schneiter R, Delahaye S, et al. Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. J Pharmacol Exp Ther 2004 308 1121-1129. 

Geier A, Wagner M, Dietrich CG, et al. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta 2007 1773(3) 283-308. 

Sasaki M, Suzuki H, Sugjyama Y (2005) Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP IB 1) /multidrug resistance-associated... 

Niemi M, Pasanen MK, Neuvonen PJ (2011) Organic anion transporting polypeptide 1B1 a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 63 157-181... 

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