Human therapeutics

Retroviral genes are replaced with therapeutic human gene, making the the retrovirus incapable of self-replication... 

Many attempts have been made to link monoclonal antibodies specific for antigenic determinants on cancer cells to protein toxins such as ricin (Box 29-A). It is hoped that this may provide an effective way of carrying toxins into cancer cells/ 1 r Therapeutic human monoclonal antibodies are already in use as antirejection drugs for kidney transplantation, for treatment of rheumatoid arthritis, Crohn disease, and for some types of cancer/... 

Immune libraries and evolutionary selection strategies intersect in the area of antibody humanization. Recently, we have extended the repertoire of methods available for the generation of therapeutic human antibodies by developing phage display strategies for the selection and humanization of antibodies from immune animals other than mice. Our aim here was to modify protein sequence, in some cases in a very radical way, and yet retain the function of the parental antibody. In the following discussion, we will focus on these novel approaches. 

Roberds SL, Anderson J, Basi G, et al. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain implications for Alzheimer s disease therapeutics. Human Molec Genet. 2001 10(12) 1317-1324. 

During MJ, Samulski RJ, Elsworth JD, Kaplitt MG, Leone P, Xiao X, Li J, Freese A, Taylor JR, Roth RH, Sladek JR, Jr, O Malley KL, Redmond DE, Jr. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Ther 1998 5 820-827. 

Therapeutic Human Polyclonals Products. http //www.polyclonals.com/index.html 2004. 

Green, L. L, Antibody engineering via genetic engineering of the mouse, XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies. J. Immunol. Methods 1999, 231(1-2), 11-23. 

Studies reported by Jaber et al. (2007) provide an excellent example of how nonclinical evaluations can lead to the selection of a less immunogenic, and more tolerable formulation of Rebif , a therapeutic human interferon beta-la (IFNP-la) biopharmaceutical. Following genetic engineering efforts to improve... 

Display technologies add a very valuable dimension to the development of therapeutic antibodies derived from human Ig mice or to antibodies developed from synthetic libraries. They provide an alternative for developing therapeutic human antibodies for targets that are either identical or similar to the mouse homologues in humanized transgenic mice. 

Kawana K, Adachi K, Kojima S, Kozuma S, Fuji T. Therapeutic human papillomavirus (HPV) vaccines a novel approach. Open Virol J. 2012 6 264-9. 

Given the level of publicity about the odious nature of chemical weapons, tests with toxic substances on humans needed not only to be carefully designed to avoid any potential risk of harm, but also to conform to existing legal and ethical guidelines relating to non-therapeutic human experiments.A key feature of the Porton experiments is that... 

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