Proto-oncogene expression

RAO G N and berk b c (1992) Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression Circulation Research 70, 593-9. 

Basset-S6guin, N., Escot, C., Blanchard, J.M., Kerai, C., Verrier, B., Moin, H. and Guilhou, J.J. (1990). High levels of c-fos proto-oncogene expression in normal human adult skin. J. Invest. Dermatol. 94, 418-422. 

Mutter, G. L and Wolgemuth, D. J. (1987). Distinct developmental patterns of c-mos proto-oncogene expression in female and male mouse germ cells. Proc. Nad. Acad. Sci. USA 88 7869-7872. 

Gribaldo, L., M.G. Sacco, S. Casati, I. Zucchi, M.K. Dosanjh, P. Catalani, and E. Marafante. 1998. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line. Jour. Toxicol. Environ. Health 55A 121-131. 

This study reports that retrovirus vector insertion into a proto-oncogene activates proto-oncogene expression, which may trigger malignancy. 

Fung H, Quinlan TR, Janssen YMW, et al. 1997b. Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells. Cancer Res 57 3101-3105. 

The Ewing family of tumors comprises small round cell neoplasms of bone and soft tissue that are, in part, defined by a particular chromosomal aberration [t(ll 22)] and variants thereof. Over the past 15 years, it has become clear that ES and peripheral PNET are part of the same spectrum of neoplastic proliferations. Besides the karyotypic marker just mentioned, both of those tumor types also show neuroectodermal features in tissue culture and similarities in proto-oncogene expression. As classically defined, ES was distinguished from PNET by an absence of pseudorosettes and the lack of ultrastructurally or immunohistochemically detectable neuroectodermal features. However, this diagnostic separation is now considered to be antiquated and has been abandoned. 

Kaliay E, Kieor O, Chattopadhyay N, Brown EM, Bischoe mg, Peterlik M and Cross HS (1997) Caldum-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells a role for a luminal extracellular caldum-sensing receptor. 

In addition to the insulin-mimetic effect of vanadium compounds, vanadium affects signal transduction mechanisms and proto-oncogene expression in vitro (Stern etal. 1993). At concentrations > 5 mM, orthovanadate is cytotoxic to proliferating cells, including primary culture and tumor cell lines (Cruz et al. 1995, Djordjevic 1995). 

Gratiot Deans, J., Ding, L., Turka, L.A. and Nunez, G. (1993) bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. J. Immunol. 151 83-91. 

The tumor-promoting activity of OA class compounds is dne to their inhibitory activity of protein phosphatases, which increases phosphorylation/activation of varions proteins involved in the signal transduction pathways regulating the cell cycle and cell transformation. ° Different effects of OA leading to transformation of cells were reported, such as induction of mitosis, ° ° cycle progression, " as well as cell proliferation genes and proto-oncogenes expression. " It has been demonstrated that OA induces the release and expression of tumor necrosis factor-a (TNF-a) and other cytokines, phosphorylation of the tnmor snppressors p53 and retinoblastoma pRb proteins, and activation and induction of the nnclear transcription factors, such as activator protein-1 (AP-1) andNF-KB. ... 

Sun, J. and Jin, T. (2008). Both Wnt and mXOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell Signal. 20, 219-229. 

Lyall, R, Deehan, M.R., Greer, I. A., Boswell, E, Brown, W.G. and Mclnnes, G.T (1994) Mechanical stretch increases proto-oncogene expression and phosphoinositide tiirnox er in vascular smooth muscle cells, J. of Hypertension, 12, 1139-1145. 

---