Noni juice

The potassium concentration in noni juice samples was 56 mmol/1. 

A man with chronic renal insufficiency who followed dietary restriction of potassium developed a raised serum potassium concentration (5.8 mmoPl). He insisted that he had followed his dietary regimen as usual, except for taking noni juice, purchased from a health food store. He was treated with sodium polystyrene sulfonate and told to stop taking noni juice. At the next check-up his potassium was still raised he said that he would never stop taking noni juice and... 

Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia)-. hidden potential for hyperkalemia Am J Kidney Dis 2000 35(2) 310-12. 

Thus, Kane s book can be perceived as being on the cautious side, although there are many mentions of medicinal uses, and an array of individual compoimds, and classes of compoimds, is presented for each herb listed. A general comment supplied that pertains to Essiac tea, Noni juice, and other herbal medicinals believed to possess extraordinary curative powers is that there may be a window of 5-10 years of trendy use, and then they fall by the wayside (Kane, 2006, p. 16). 

A man had a rise in his INR after stopping taking a herbal nutritional supplement (Nature s life Greens), which contained a number of plants known to be high in vitamin K. Another patient had a decrease in INR after starting to drink a plant extract juice (called Noni Juice). 

Acquired coumadin resistance and decreased INR (a standardized scale used to report the results of blood coagulation tests decreased INR indicates faster blood clotting) were reported in a 41-year-old woman who had been consuming "two small glasses" daily of noni juice for an unspecified length of time. The reporting physicians... 

Animal studies on the use of noni provide conflicting information, with one study showing no adverse effects on development at very large (6 g/kg) doses, while another study indicated that use of noni juice in pregnancy caused a delay in fetal bone formation (Marques et al. 2010 West etal. 2008). 

Hepatotoxicity was reported in a 45-year-old man who had been consuming "a glass" of noni juice daily for approximately 3 weeks. Highly elevated transaminase and gamma-glutamyltransferase (GGT), elevated lactate... 

A 29-year-old man with a history of toxic hepatitis associated with small doses of paracetamol developed subacute hepatic failure following consumption of 1.5 liters of noni juice over a 3-week period. He was also taking approximately 7 g daily of a Chinese herbal remedy containing Bupleurunt, Pinellia, Scutellaria, Codonopsis, Glycyrrhiza, Schizonepeta, and Paeonia. Liver function tests indicated elevated levels of bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransfer-ase (GGT), and alkaline phosphatase (ALP) (Stadlbauer et al. 2005). 

A 62-year-old woman with no history of liver disease developed an episode of self-limited acute hepatitis following consumption of 2 liters of noni juice over a 3-month period. A percutaneous liver biopsy revealed acute hepatitis consistent with an idiosyncratic drug reaction. Elevated levels of AST, ALT, and bilirubin were observed and returned to normal after cessation of noni. The woman had been treated the previous year with fludarabine for chronic B-cell leukemia (Stadlbauer et al. 2005). 

Acute hepatitis was reported in a 24-year-old woman with multiple sclerosis who had been consuming noni juice (dose and frequency not specified) for 4 weeks. The woman had been treated with interferon bla (IFN) for 6 weeks, a drug that commonly causes hepatic dysfunction of varying severity in multiple sclerosis patients (Francis et al. 2003). IFN was initially suspected as the cause of hepatotoxicity in this case. IFN administration was ceased, and approximately 1 week later noni was ceased. Liver enzyme levels (ALT and bilirubin) increased dramatically for 2 weeks after cessation of IFN and then returned to normal levels (Yuce et al. 2006). 

Hepatotoxicity was reported in a 43-year-old man who had been recently diagnosed with a malignant brain tumor (glioblastoma). The man had consumed 20 ml daily of noni juice for 2 weeks and was also taking levetiracetam twice daily (Stadlbauer et al. 2008). Hepatotoxicity was reported in a 33-year-old woman who had consumed several doses of noni (amount unspecified) over a period of several weeks (Lopez-Cepero Andrada et al. 2007). 

No allergic reactions were observed in guinea pigs subjected to sensitization and challenge tests with noni juice (Kaaber 2000 Product Safety Labs 2000). 

In rats orally administered 0.4, 2, or 20 ml/kg of noni aqueous extract or 0.4, 2, or 20 ml/kg of noni juice on days 7 to 15 of pregnancy, ossification in fetuses was delayed. No signs of maternal toxicity were observed (Marques et al. 2010). 

Davies, C., and C. Mugglestone. 2003. A single centre, doubleblind, three dose level, parallel group, placebo controlled safety study with Tahitian noni juice in healthy subjects Surrey, UK BIBRA International Ltd. 

EC. 2003. EU Commission Decision of 5 Jime 2003 authorising the placing on the market of "noni juice" (juice of the fruit of Morinda citrifolia L.) as a novel food ingredient imder Regulation (EC) No 25% 197 of the European Parliament and of the Council. 

Edwards, C. 2002. Tahitian noni juice—Mouse micronucleus test. Test report. Lille Skensved, Denmark Scantox Biologisk Laboratorium. 

A slight mutagenic effect of noni juice extract was observed in the Salmonella microsome assay in strain TA1537 but not in strains TA98 or TAIOO. The activity was attributed to the presence of flavonoids (Westendorf et al. 2007). No mutagenicity of noni juice was observed in the mammalian mutagenicity test with V79 Chinese hamster fibroblasts (Westendorf et al. 2007). Rats treated with a noni juice concentrate did not show DNA repair synthesis in primary rat hepatocytes, nor could DNA adducts or DNA strand breaks be observed (Westendorf et al. 2007). 

No clastogenic activity of noni was observed in mice orally administered a single dose of 10 g/kg of the dehydrated juice. Observation of bone marrow showed no increase in micronuclei related to ingestion of noni juice (Edwards 2002). 

No activity of noni juice at concentrations of 625,1250, 2500, and 5000 /fg/rnl (dry weight) was observed in the chromosomal aberration test with human lymphocytes with or without metabolic activation from S9 mix (Edwards 2003). 

EFSA. 2006. Opinion on request from the Commission related to safety of noni juice (juice of the fmits of Morinda citrifolia). EFSA. 376 1-12. 

Glerup, P. 2000. Tahitian noni juice—A 13-wk oral (gavage) toxicity study in rats. LiUe Skensved, Denmark Scantox Biologisk Laboratorium. 

Stadlbauer, V., P. Fickert, C. Lackner, et al. 2005. Hepatotoxicity of noni juice Report of two cases. World. Gastroenterol. ll(30) 4758-4760. 

Yuce, B., V. GuBbeig, J. Diebold, and A.L. Gerbes. 2006. Hepatitis induced by noni juice from Morinda citrifolia A rare cause of hepatotoxicity or the tip of the iceberg Digestion 73(2-3) 167-170. 

If you ve ever wondered why ice melts under a skate or why meat is red or where the colours of flowers come from, you will wonder no more. No longer will you be at the mercy of advertisers who make questionable claims about noni juice, glucosamine, bottled water, aromatherapy and homeopathy. Confusion about the placebo effect, brown versus white sugar, blood doping, DDT, dioxins and the ozone layer will be seen to evaporate with the infusion of sound science. You will even discover why you don t need hot water to make a hard-boiled egg and why drags and grapefruit juice do not mix. 

Liver Hepatotoxicity related to the consumption of noni juice, prepared from the fruits of Morinda dtrifolia, has again been reported [71 ]. 

A 43-year-old white man with a glioblastoma underwent surgery and was scheduled for radiation and chemotherapy. After drinking noni juice 20 ml bd for 2 weeks, he developed raised aminotransferases in routine prechemotherapy blood tests. The aminotransferases returned to normal as soon as he stopped drinking noni juice. 

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