Salmonella microsomes assay

Zeiger E, Haworth S. 1985. Tests with a preincubation modification of the Salmonella/microsome assay. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 187-199. 

Matheson et al. (1978) reported the results of a battery of in vivo and in vitro assays to assess the genotoxicity of 1,1-dimethylhydrazine. Included were the Ames Salmonella microsome assay, a microbial suspension assay, mutation induction at the TK locus in L5178Y mouse lymphoma cells, stimulation of UDS in WI-38 cells, and a dominant lethal assay in mice. 1,1-Dimethylhydrazine was active in all of the tests except the dominant lethal assay. 

Mutagenicity in the Ames Salmonella/microsome assay 97 Anticancer activity of iV-acyloxy-iV-alkoxyamides 115... 

IV-acyloxy-iV-alkoxyamides, biological activity, 97-115 anticancer activity of, 115 mutagenicity of, in Ames Salmonella/ microsome assay, 97-115 IV-acyloxy-iV-alkoxyamides, chemical reactivity, 59-96 factors contributing, 59-60 nucleophilic substitution reactions, see Nucleophilic substitution reactions solvolysis studies, see Solvolysis... 

Barber ED, Donish WH, Mueller KR. 1981. A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella/microsome assay. Mutat Res. 90 31-48. 

In Chapter 1 Bruce N. Ames, the plenary speaker at the symposium, describes the development of the Salmonella/microsome assay, which is better known as the Ames Test. This test was the first proven rehable and rapid in-vitro method for the mutagenic and carcinogenic screening of chemicals. Included is an excellent overview of the potential problem of human exposure to toxic substances as well as a description of how this important method is being used to test chemical substances. 

NT148 Cerna, M. and K. J. Angelis. Mutagenicity in the Salmonella/microsome assay of tobacco condensates formed during pipe smoking. Mutat Res 1985 143(3) 161-164. 

S. V. Bhide. Mutagenicity of gingerol ZO063 and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay. Cancer Lett 1987 36(2) 221-233. ZO064... 

Greibrokk, T., G. Lofroth, L. Nilsson, R. Toftgard, J. Carlstedt-Duke, and J. Gustafsson, Nitroarenes Mutagenicity in the Ames Salmonella./Microsome Assay and Affinity to the TCDD-Recep-tor Protein, in Toxicity of Nitroaromatic Compounds (D. E. Rick-ert, Ed.), pp. 166-183, Hemisphere Publishing, Washington, DC, 1985. 

Nagao, M. Takahashi, Y. (1981) Mutagenic activity of 42 coded compounds in the Salmonella microsome assay (National Cancer Center Research Institute). In de Serres, F.J. Ashby, J., eds. Progress in Mutation Research. Vol. 1, Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Program, Amsterdam, Elsevier/North-Holland. pp. 302-313... 

Wehner FC, van Rensburg SJ, Thiel PG. Mutagenicity of marijuana and Transkei tobacco smoke condensates in the Salmonella/microsome assay. Mutat Res 1980 77(2) 135-42. 

Salmonella/microsome assay with preincubation. Mutat Res 1 261-270. 

Richold M, Jones E. 1981. Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay. In Evaluations of short-term tests for carcinogens Report of the international collaborative program. Prog Mutat Res 1 314-322. 

Hass BS, Brooks EE, Schumann KE, et al. 1981. Synergistic, additive, and antagonistic mutagenic responses to binary mixtures of benzo(a)pyrene and benzo(e)pyrene as detected by strains TA98 and TAI 00 in the Salmonella/microsome assay. Environ Mutagen 3(2) 159-166. 

Genotoxicity studies (Salmonella microsome assays, sister chromatid exchange, and tests of unscheduled DNA synthesis and of chromosome aberrations in cultured mammalian cells) indicate that selenite, selenate, and selenide have both genotoxic and antigenotoxic effects (Biswas et al. 1997, 2000 Gairola and Chow 1982 Khalil 1994 Lu et al. 1995b Schillaci et al. 1982 Ueda et al. 1997 van der Lelie et al. 

Azizan A and Blevins RD (1995). Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay. Arch Environ Contamin Toxicol, 28, 248-258. 

Genotoxic Effects. There are some data on in vitro genotoxicity of carbon disulfide. Haworth et al. (1983) evaluated carbon disulfide at five doses both with and without S9 activation in the Salmonella/microsome assay. All results were negative. Other studies in Salmonella typhimurium and Escherichia coli, both with and without activation, were also negative (Donner et al. 1981 Hedenstedt et al. 1979). Salmonella strain TA98 was used in a host-mediated assay investigating the ability of carbon... 

Krewsi D, Leroux BG, Creason J, et al. 1992. Sources of variation in the mutagenic potency of complex chemical mixtures based on the salmonella/microsome assay. Mutat Res 276 33-59. 

Marvin CH, McCarry BE, Villella J, et al. 2000. Chemical and biological profiles of sediments as indicators of sources of contamination in Hamilton Harbour. Part II Bioassay-directed fractionation using the Ames Salmonella/microsome assay. Chemosphere 41 989-999. 

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