Neisseria meningitidis

Meropenem (Merrem IV) inhibits syndiesis of die bacterial cell wall and causes die deadi of susceptible cells. This drug is used for intra-abdominal infections caused by Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and odier susceptible organisms Meropenem also is effective against bacterial meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, and Hemophilus influenzae. 

Virus infections such as influenza and the common cold (in reality 300-400 different strains ofrhinovirus) infect epithelial cells ofthe respiratory tract and nasopharynx, respectively. Release ofthe virus, after lysis ofthe host cells, is to the void rather than to subepithelial tissues. The epithelia is further infected resulting in general degeneration ofthe tracts. Such damage predisposes the respiratory tract to infection with opportunistic pathogens such as Neisseria meningitidis and Haemophilus influenzae. 

The treatment of bacterial infections of the central nervous system highlights a number of important therapeutic considerations. Bacterial meningitis is caused by a variety of bacteria although their incidence varies with age. In the neonate, E. coli and group B streptococci account for the majority of infections, while in the preschool child H. influenzae is the commonest pathogen. Neisseria meningitidis has a... 

Type B vaccine, the Neisseria meningitidis Type A and C vaccine, the 23-valent pneumococcal polysaccharide vaccine and an acellular typhoid vaccine. 

Fractionation. The process by which components are extracted firm bacterial eells or from the medium in whieh the baeteria are grown and obtained in a purified form. The polysaccharide antigens of Neisseria meningitidis are separated from the bacterial cells by treatment with hexadecyltrimethylammonium bromide and those of Streptococcus pneumoniae with ethanol. The purity of an extracted material may be improved by resolubilization in a suitable solvent and precipitation. After purification, a component may be dried to a powder, stored indefinitely and, as required, incorporated into a vaccine in precisely weighed amounts at the blending stage. 

Neisseria meningitidis Types A and Ct, Cultures of N. meningitidis of serotypes A and C 1 Precipitation with hexadecyl-trimethyammonium bromide 2 Solubilization and purification 3 Blending 4 Freeze-drying Estimation of capsular polysaccharide content ... 

Neisseria meningitidis Penicillin MIC 0.1 mg/L Standard Therapy Penicillin G 4 million units IV every 4 hours or Ampicillin 2 g IV every 4 hours Hypersensitivity (rash, anaphylaxis), diarrhea Hypersensitivity (rash, anaphylaxis), 7... 

A number of Gram-negative microorganisms, including the important human pathogens Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae,... 

Girgis N, Sultan Y, Frenck RW Jr, El-Gendy A, Farid Z, Mateczun A Azithromycin compared with rifampin for eradication of nasopharyngeal colonization by Neisseria meningitidis. Pediatr Infect Dis J 1998 17 816— 819. 

Cuevas LE, Kazembe P, Mughogho GK, Til-lotson GS, Hart CA Eradication of nasopharyngeal carriage of Neisseria meningitidis in children and adults in rural Africa A comparison of ciprofloxacin and rifampicin. J Infect Dis 1995 171 728-731. 

Cresti S, Giordano I, Donati E, Giaccherini R, Barberi A, Cellesi C Prevalence and che-mosusceptibility of Neisseria meningitidis and Haemophilus influenzae in a population of central Italy. New Microbiol 2003 26 281-288. 

Live attenuated strains of measles virus Purified surface polysaccharide antigens of one or more strains of Neisseria meningitidis... 

CNS infections may be caused by a variety of bacteria, fungi, viruses, and parasites. The most common causes of bacterial meningitis include Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes, and Haemophilus influenzae. 

Gram-negative Neisseria meningitidis Penicillin susceptible Penicillin G or ampicillin (A-lll) Cefotaxime (A-lll), ceftriaxone (A-lll), chloramphenicol (A-lll) 7 days... 

PRP-OMP PedvaxHIB (Merck) Neisseria meningitidis serogroup B outer membrane protein... 

The first transporter of this type characterised as an iron-supply system that functions in the absence of any siderophore was the Sfu system of S. marcescens [224]. Later, similar systems were reported from Neisseria gonorrhoea and Neisseria meningitidis, and have been detected by analysing the genomes of a variety of bacteria, e.g. Actinobacillus pleuropneumoniae, B. halodurans, Campylobacter jejuni, Ehrlichia chaffeensis, Halobacterium sp., H. influenzae,... 

The serotype A polysaccharide of Neisseria meningitidis was already known to have a repeating unit consisting of a (1— 6)-linked 2-acetamido-2-deoxy-D-mannopyranosyl phosphate partly substituted... 

Fig. 31.— 13C-N.m.r. Spectra of Native Neisseria meningitidis Serogroup A Polysaccharide (A 27 and 28) and O-Deacetylated Product (B 28). [Solvent, D20 at 37° the spectral-shift axis is based on external tetramethylsilane (8C = 0).]...

Fig. 34.— 13C-N.m.r. Spectra of Native, Partly Acetylated Polysaccharide from Neisseria meningitidis Serogroup C (A) and the a-D-(2— 9)-Linked N-Acetyl-D-neuraminic acid Polymer (32) Obtained on O-Deacetylation (B). (Solvent, D20, pD 7, at 31° chemical shifts are expressed relative to external tetramethylsilane.)...

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