Neisseria meningitidis serogroup

PRP-OMP PedvaxHIB (Merck) Neisseria meningitidis serogroup B outer membrane protein... 

Fig. 31.— 13C-N.m.r. Spectra of Native Neisseria meningitidis Serogroup A Polysaccharide (A 27 and 28) and O-Deacetylated Product (B 28). [Solvent, D20 at 37° the spectral-shift axis is based on external tetramethylsilane (8C = 0).]...

Fig. 34.— 13C-N.m.r. Spectra of Native, Partly Acetylated Polysaccharide from Neisseria meningitidis Serogroup C (A) and the a-D-(2— 9)-Linked N-Acetyl-D-neuraminic acid Polymer (32) Obtained on O-Deacetylation (B). (Solvent, D20, pD 7, at 31° chemical shifts are expressed relative to external tetramethylsilane.)...

Similar reasoning (see Table IX) showed that the structure of the non-O-acetylated polysaccharide of Neisseria meningitidis serogroup W135 (for its 13C-n.m.r. spectrum, see Fig. 35,C) is closely related, containing D-galactopyranosyl in place of D-glucopyranosyl residues (in 33). 

Observation of displacement effects resulting from O-substitution, and use of standards, led to the assignment of the chemical structure of the polysaccharide of Neisseria meningitidis serogroup 29e, which consists of 2-acetamido-2-deoxy-D-galactosyl and partly acetylated 3-deoxy-D-manno-octulosylonic acid (KDO) residues.166 The 13C-n.m.r. spectrum of the O-deacetylated polymer (see Fig. 36,B) contained 15 signals out of the possible 16 expected from an alternating structure. Comparison of these resonances with those of the anomers of 2-aceta-... 

The first report of the occurrence of KDO in a structure other than LPS was that of Taylor47 on the capsular polysaccharide (K-antigen) of a clinical isolate, Escherichia coli LP1092. Almost simultaneously, Bhattachaijee and coworkers83 described an exopolysaccharide from Neisseria meningitidis serogroup 29e. This material contains KDO... 

Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A. and Smith I.C.P. (1975) Structural determination of the sialic polysaccharide antigens of Neisseria meningitidis serogroup B and C with carbon 13 nuclear magnetic resonance. J. Biol. Chem. 250 1926-1932... 

Neisseria meningitidis serogroup K polysaccharide is composed of two iV-acetyl-(3-D-mannuronic acids, one of which is O-acetylated [-(l-4)-P-D-ManAAcA-(l-3)- 3-D-(490-Ac)-ManAAcA-]n [207]. It was shown to adopt the expected conformation with the protons across the glycosidic bonds HlAand H3B or H1B and H4A to be close together as demonstrated by large H-NMR nuclear Overhauser enhancements. 

Richmond P, Goldblatt D, Fusco PC, Fusco JD, Heron I, Clark S, Borrow R, Michon F. Safety and immunogenicity of a new Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in healthy adults. Vaccine 1999 18(7-8) 641-6. 

So far, the acceptor specificity of nearly 20 eu- and prokaryotic sialyltransferases has been elucidated and 15 different cDNA clones of these enzymes have been obtained (Table 14 and references therein). This list demonstrates the rapid progress in this field and also includes the first cloning of mammalian polysialyltransferase (polysialyltransferase-1 from hamster ovary cells) [620]. The same group has recently published the molecular analysis of the biosynthetic pathway of the a-2,8-polysialic acid capsule by Neisseria meningitidis serogroup B [658]. 

Moe G R, Tan S, Granoff D M (1999). Molecular mimetics of polysaccharide epitopes as vaccine candidates for prevention of Neisseria meningitidis serogroup B disease. FEMS Immunol. Med. Microbiol. 26 209-226. 

Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate... 

For active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135 when administered to individuals 11 through 55 years of age... 

Shan XY, Zhang J, Zhou HJ, Zhu BQ, Xu L, Shao ZJ, Jiang BF. Genetie diversity of Neisseria meningitidis serogroup C ST-4821 in China based on multiple-locus variable number tandem repeat analysis. Plos ONE. 2014 9(1 l)ell 1866. 

The disaccharide 9-0-a-A-acetylneuraminyl-)V-acetylneuraminic acid has been isolated following partial acidic hydrolysis of the homopolysaccharide from Neisseria meningitidis serogroup Serogroup C meningococcal polysac-... 

The capsular polysaccharide antigen of Neisseria meningitidis serogroup 29-e, composed of equimolar amounts of 2-acetamido-2-deoxy-D-galactose and 3-deoxy-D-wawio-octulosonic acid (KDO), has been identified, using a combination of chemical and n.m.r. spectroscopic techniques, as a linear polysaccharide having alternative sequences of the two residues (16). ... 

The E. coli Kl polysaccharide is composed of a2,8-linked Neu5Ac. Identical capsules have also been fotmd in Neisseria meningitidis serogroup B, Moraxella... 

Bhattacharjee AK, Jennings HJ, Kenny CP, Martin A, Smith IC (1976) Structural determination of the polysaccharide antigens of Neisseria meningitidis serogroups Y, W-135, and BOl. Can J Biochem 54 1-8... 

Deoxy-D-mfmw-octulosonic acid has been identified as the principal component (53%) of the capsular polysaccharide antigen of Neisseria meningitidis serogroup 29-e. ... 

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