Myeloid cells neutrophils

Staining Applications Mitochondria " blood samples leukocytes cells microbes granulocytes epithelial cells myeloid cells neutrophils ... 

Expression (Mouse) Tissues lungs, Cells myeloid leukocytes, neutrophils, T-cells, macrophages, mast cells, eosinophils Tissues lung, skin, small intestine Cells macrophages, fibroblasts, leukocytes Tissues lung, skin, brain, small intestine, spleen Cells macrophages, fibroblasts, endothelial cells, leukocytes... 

Hematopoiesis is defined as the development and maturation of blood cells and their precursors. In utero, hematopoiesis may occur in the liver, spleen, and bone marrow. However, after birth, it occurs exclusively in the bone marrow. All blood cells are generated from a common hematopoietic precursor, or stem cell. These stem cells are self-renewing and pluripotent and thus are able to commit to any one of the different lines of maturation that give rise to platelet-producing megakaryocytes, lymphoid, erythroid, and myeloid cells. The myeloid cell line produces monocytes, basophils, neutrophils, and eosinophils, whereas the lymphoid stem cell differentiates to form circulating B and T lymphocytes. In contrast to the ordered development of normal cells, the development of leukemia seems to represent an arrest in differentiation at an early phase in the continuum of stem cell to mature cell.1... 

Kofoed, K., et al. (2007) Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections a prospective study. Crit Care. 11, R38. 

Interleukin-11 acts through a specific cell surface cytokine receptor to stimulate the growth of multiple lymphoid and myeloid cells. It acts synergistically with other growth factors to stimulate the growth of primitive megakaryocytic progenitors and, most importantly, increases the number of peripheral platelets and neutrophils. 

G-CSF IL-1, LPS Granulocyte colony stimulation, terminal differentiation of myeloid cells, enhanced neutrophil function — Granulocytes, myeloid stem cells, neutrophils... 

Rohovsky, Newberne and Gibson17 reported the appearance of vacuolation and granulation of peripheral leucocytes in the mouse, rat, dog and monkey. A concomitant alteration in the reticuloendothelial system also occurred which consisted of intracytoplasmic accumulation of ovoid structures with vacuolated centers in Kupffer cells of the liver and mixed macrophages of the spleen and lymph nodes. Smears of bone marrow revealed abnormal granules in myeloid cells as primitive as neutrophilic myelocytes, but the myeloid erythoid ratio was not altered. The post-treatment regression of these effects was species dependent. 

CDllc member of b2 of integrin receptor family also called integrin alpha X, CR4, LeuM5. Clears opsonized par deles and immune complexes also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium. Myeloid cell marker. 

A 55-year-old woman who was taking terbinafine and paroxetine presented with fever, diarrhea, and vomiting. A bone marrow biopsy showed overall reduced ceUularity, and the aspirate showed a profound shift toward the production of immature myeloid cells, consistent with maturation arrest. Treatment consisted of withdrawal of all outpatient medications, hydration, intravenous fluids, broad-spectrum antibiotics, and G-CSF 5 pg/kg for 5 days. Mature granulocytes appeared in the peripheral blood on the fifth day in hospital, and she was discharged on the seventh hospital day with an absolute neutrophil count of 6.2 x 10 /1. Paroxetine was resumed weeks after discharge from hospital without hematological toxicity over 6 months. 

The phagocytic cells, i.e., neutrophils, monocytes, macrophages, and dendritic cells, are myeloid cells that actively participate in innate immunity and are one lineage of stem cell differentiation (Table 35-1). Mutations in myeloid cells are one of the causes of the myelocytic leukemias. 

Promotes chemotaxis and granule release by neutrophils, basophils, T cells Mitogenic for myeloid cells, supports antigen-independent growth of helper T cells Inhibits interferon secretion, induces thymocyte proliferation in presence of other IL s, inhibits Thl cytokine production Induction of synthesis of acute phase proteins, enhances stimulation of hematopoietic cell proliferation by IL-3 and T-cell development of B cells Activates NK cells, stimulates production of IFN-a by Thl cells... 

GM-CSF Granulocyte-macrophage colony-stimulating factor, a hematopoietic growth factor that stimulates production of granulocytes (basophils, eosinophils, and neutrophils), and other myeloid cells... 

Burn TC, Petrovick MS, Hohaus S, Rollins BJ, Tenen DG Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines. Blood 1994 84 2776-2783. 

Caldenhoven et al. [43] demonstrate that, in addition to STATla, STAT3 was also activated by IFN-7 in human PMNs. GM-CSF was reported to activate Jak-2, STATl, STAT3, and STATSb but not Jak-1, Jak-3, or Tyk-2, STAT2, STAT4, or STAT6 [28,44,45], In other studies, STATS was found to be involved in myeloid cell proliferation and neutrophil differentiation and Jak-2 was activated in neutrophils from patients with severe congenital neutropenia [46, 47],... 

Ilaria RL Jr, Hawley RG, Van Etten RA Dominant negative mutants implicate STATS in myeloid cell proliferation and neutrophil differentiation. Blood 1999 93 4154-4166. 

Macrophage, monocytes, osteoclasts, KupfFer cells, mast cells, synovial cells, microglia, dendritic cells, fibroblasts, Langerhans cells, myeloid cells, CD34+ progenitor cells, neutrophils, B- and T-cells... 

---