Neutrophils, differentiation

Mollinedo F, Lopez-Perez R, Gajate C (2008) Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells. Gene 419 16-26... 

Madema P, Cottefl DC, Berlasconi G, Petasis NA, Brady HR, Godson C (2002) Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils differential involvement of rho GTPases. Am J Pathol 160 2275-2283... 

Alberich Jorda M, Rayman N, Tas M, Verbakel SE, Battista N, Van Lorn K, Lowenberg B, Maccarrone M, Delwel R (2004) The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a hgand-dependent manner. Blood... 

The possibility that the CB2 receptor plays a role in the control of immune cell fate is supported by studies on the gene expression profile ofhuman promyelocytic cells, which show that receptor activation up-regulates genes involved in the cell differentiation program (Derocq et al. 2000). These data, together with reports of CB2-induced blockade of neutrophilic differentiation (Alberich Jorda et al. 2003) and changes in CB2 receptor expression during the differentiation and activation ofhuman B cells (Carayon et al. 1998) point to an involvement of the CB2 receptor in the control of immune cell maturation. 

Alberich Jordi M, Lowenberg B, Delwel R (2003) The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation. Blood 101 1336-1343... 

Thompson BY, Sivam G, Britigan BE, Rosen GM, Cohen MS. Oxygen metabolism of the HL-60 cell line comparison of the effects of monocytoid and neutrophilic differentiation. Journal of leukocyte biology 1988 43 140-7. 

Elbim C, Reglier H, Fay M, Delarche C, Andrieu Y El Benna J, Gougerot-Pocidalo M-A Intracellular pool of IL-10 receptors in specific granules of human neutrophils differential mobilization by proinflammatory mediators. J Immunol 2001 166 5201-5207. 

Caldenhoven et al. [43] demonstrate that, in addition to STATla, STAT3 was also activated by IFN-7 in human PMNs. GM-CSF was reported to activate Jak-2, STATl, STAT3, and STATSb but not Jak-1, Jak-3, or Tyk-2, STAT2, STAT4, or STAT6 [28,44,45], In other studies, STATS was found to be involved in myeloid cell proliferation and neutrophil differentiation and Jak-2 was activated in neutrophils from patients with severe congenital neutropenia [46, 47],... 

Ilaria RL Jr, Hawley RG, Van Etten RA Dominant negative mutants implicate STATS in myeloid cell proliferation and neutrophil differentiation. Blood 1999 93 4154-4166. 

Santos-Beneit AM, Mollinedo F Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells. J Leukoc Biol 2000 67 712-724. 

Gramulocyte-colony stimulating factor (G-CSF) is a well-known neutrophil differentiation factor and is clinically used to increase neutrophil numbers after the treatment with antitumor medicines. 

Tsai, S. and Collins S. J. (1993) A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage. Proc. Nat Acad Sci. USA 90,7153-7157. 

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