Leukocyte T Cells

Migration of leukocytes, T cells, and B cells is directed by extracellular diffusible chemicals known as chemokines (1). These chem-okines are detected by G-protein-coupled receptors (GPCRs) on the cell surface, which in turn activate (dissociate) heterotrimeric G-proteins on the inner cell membrane (1-3). The dissociation of G-proteins into Ga and GPy subunits triggers multimolecular... 

Azzawi et al. reported similar results (30). They compared the number of leukocytes, T cells, B cells, and eosinophils in a 115-pm deep layer beneath the lamina reticularis of intrapulmonary bronchi in healthy people who died of drowning or in road accidents and in those who died of an asthma attack lasting for several hours. These data are summarized in Table 8. 

From this table, it is clear that the asthmatics differed from the healthy subjects in the number of leukocytes, T cells, and eosinophils in these larger airways. Azzawi and colleagues also correlated the number of eosinophils present and the duration of the terminal episode, which ranged from a few hours to several days. The longer the duration, the higher the eosinophil count in the airways (30). 

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