Multiple site

Gilson, M. K. Multiple-site titration and molecular modeling Two rapid methods for computing energies and forces for ionizable groups in proteins. Proteins Struct. Punct. Genet. 15 (1993) 266-282. 

Bashford, D., Karplus, M. Multiple-site titration curves of proteins an analysis of exact and approximate methods for their calculation. J. Phys. Chem. 95 (1991) 9556-9561. 

Unlike idoxuridiae, BVdU, and acyclovir, viral strains susceptible to ribavirin have not been found to develop a resistance to the dmg. The resistance against ribavirin is less likely because the dmg exhibits multiple sites of antiviral action. 

Obviously, the risk of hazardous chemicals is reduced by a minimized inventory using just-in-time procurement. If further inventory reduction is not feasible, additional risk reduction may be achieved by dispersing the inventory to multiple site locations so a release in one location does not allcci other locations of inventory. 

If you have one quality system, the roles of management representative and quality director become difficult to separate and can cause a conflict of interest unless the management representative is the CEO. In large organizations with multiple sites, each with separate ISO 9000 registrations, a more appropriate solution is to have a management representative for each site and one quality director for the whole organization. 

Encourage auditors and assessors to review and organize their notes as soon as possible after completing an interview or site visit. It s easy to lose track of insights and observations if too much time elapses, particulady when an assessment involves multiple sites. 

Ozin and Huber 112) synthesized and characterized very small silver particles, Ag n = 2-5) by conventional deposition methods, as well as by a novel technique that they have termed "cryophotoaggrega-tion. This study will be discussed in detail in Section III. Of interest here is a study of silver atoms and small, silver clusters entrapped in ice and high-molecular-weight paraffin (n-C22H46, n-C32Hg8) matrices 146) (see Figs. 7 and 8, and Tables IV and V). Besides the intriguing, multiple-site (solvation) occupancy of atomic silver in ice matrices, and their thermal and photochemical interconvertibility, their extremely... 

Work has also been conducted that involved the investigation, via infrared spectroscopy, of matrix-isolated, plutonium oxides (40), with the appropriate precautions being taken because of the toxicity of plutonium and its compounds. A sputtering technique was used to vaporize the metal. The IR spectra of PuO and PUO2 in both Ar and Kr matrices were identified, with the observed frequencies for the latter (794.25 and 786.80 cm", respectively) assigned to the stretchingmode of Pu 02. Normal-coordinate analysis of the PUO2 isotopomers, Pu 02, Pu 02, and Pu 0 0 in Ar showed that the molecule is linear. The PuO molecule was observed in multiple sites in Ar matrices, but not in Kr, with Pu 0 at 822.28 cm" in the most stable, Ar site, and at 817.27 cm" in Kr. No evidence for PuOa was observed. 

For multiple sites F(x) is obtained by assuming a distribution of rate constants. The summations in Equation 9 are then... 

There are four main types of architectural options when implementing LIMS [6]. The first is the LAN (local area network) installation. In a multiple-site situation and through the standard client/server setup, the application would be hosted separately on a server at each site connected to PC clients. In this setup, the LIMS are installed on both the clients and the server. System administration is required at each facility. 

Many proteins can be phosphorylated at multiple sites or are subject to regulation both by phosphorylation-dephosphorylation and by the binding of allosteric ligands. Phosphorylation-dephosphorylation at any one site can be catalyzed by multiple protein kinases or protein phosphatases. Many protein kinases and most protein phosphatases act on more than one protein and are themselves interconverted between active and inactive forms by the binding of second messengers or by covalent modification by phosphorylation-dephosphorylation. 

The multiple sites that serve as origins for DNA replication in eukaryotes are poorly defined except in a few animal viruses and in yeast. However, it is clear that initiation is regulated both spatially and temporaUy, since clusters of adjacent sites initiate rephcation synchronously. There are suggestions that functional domains of chromatin replicate as intact units, implying that the origins of rephcation are specificaUy located with respect to transcription units. 

Measles, mumps and rubella (German measles) are infectious diseases, with respiratory routes of transmission and infection, caused by members of the paramyxovirus group. Each virus is immunologically distinct and has only one serotype. Whilst the primary multiplication sites of these viruses is within the respiratory tract, the diseases are associated with viral multiplication elsewhere in the host. 

Barriault D, M Sylvestre (2004) Evolution of the biphenyl dioxygenase BphA from Burkholderia xenovorans LB400 by random mutagenesis of multiple sites in Region III. J Biol Chem 279 47480 7488. 

Mormille MR, S Liu, JM Suflita (1994) Anaerobic biodegradation of gasoline oxygenates extrapolation of information to multiple sites and redox conditions. Environ Sci Technol 28 1727-1732. 

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