Nucleic acids multiple metal-binding sites

Overall, these results confirm the above conclusion that a purine-coordinated Pt " unit affects metal ion binding at the phosphate group of the same nucleotide only relatively little. This is of relevance for multiple metal ion binding to nucleotides and nucleic acids as is the already discussed result (Section 4.1) regarding (Dien)Pt(9EtG-A7) and its metal ion-binding properties, which are, despite the Pt " at N7 of the guanine residue, still quite remarkable at the (Nl) site [82] (see also ref. [69]). 

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