Site multiplicity effects

The multiple effects of UFH on the coagulation cascade may increase its potential to cause hemorrhage." Anticoagulants with more specific sites of action may confer a better safety profile. Two such anticoagulants are low-molecular-weight heparin (LMWH) and heparinoids. 

In general, the absence of a negative ion will endow a site with a positive effective charge. Multiple effective positive charges can exist and are written using superscript n . An oxide ion (O2-) vacancy in a crystal of CaO will bear an effective positive charge of... 

General Functions of Octopamine in Arthropods. The actions of OA in invertebrates therefore are multiple and probably involve both central and peripheral sites. Moreover, as pointed out previously, many of the known actions of OA are comparable to those of NE and E in the vertebrate central and sympathetic nervous systems. These multiple effects are concerned with arousal and stress responses, increasing the responsiveness to outside stimuli, and alerting the resting animal and priming it for action and movement. It is interesting, though inconclusive, in this context to note that ants... 

The hb-PAEs of hb-P13 and hb-P15 contain NLO-active azo-functionalities, which are soluble, film-forming, and morphologically stable (Tg > 180 °C). Their poled films exhibited high SHG coefficients ( 33 up to 177pm/V), thanks to the chromophore-separation and site-isolation effects of the hyperbranched structures of the polymers in the three-dimensional space (Table 5) [28]. The optical nonlinearities of the poled films of the polymers are thermally stable with no drop in d33 observable when heated to 152 °C (Fig. 8), due to the facile cross-linking of the multiple acetylenic triple bonds in the hb-PAEs at moderate temperatures (e.g., 88 °C). 

The composition of an alloy surface is often very different than the alloy s bulk composition due to segregation effects. The overall activity of a catalyst is determined by the distribution of active sites. This distribution may be very heterogeneous both in terms of the local environments that define each site and their chemical reactivities. The reactivity of any specific active site can be affected by contributions from strain, ligand and ensemble effects. Computational methods are well suited to exploring these effects because one can simulate model systems where only one effect dominates as well as model systems where multiple effects are important. 

Synthetic AFl and AF2 have potent biological activity on the neuromuscular system of A. suum. Injection of AFl or AF2 produced a local paralysis near the injection site. In a muscle strip preparation, both AFl and AF2 produced multiple effects on muscle tension, including relaxation, contraction, and induction of rhythmic activity (196,197). Intracellular recording techniques show that AFl, at 10 -10 m, short-circuits electrical activity in inhibitory, but not excitatory motoneurons by opening channels in their membranes (194). The input resistance of these cells is drastically reduced by AFl this effect is due, at least in large part, to the presence of receptors for AFl on the inhibitory motoneuron since, when synaptic transmission is blocked with Co, the... 

This graph shows the effects the way they really are. Note, however, that as the variables increase, the number of interaction terms skyrockets, eating valuable degrees of freedom. Perhaps, a better way to perform this study would be to separate the anatomical sites, because their results are not compared directly anyway, and use a separate statistical analysis for each. However, by the use of dummy variables, the evaluation can be made aU at once. There is also a strong argument to do the study as it is, because the testing is performed on the same unit—a patient—just at different anatomical sites. Multiple analysis of variance could also be used where multiple dependent variables would be employed, but many readers would have trouble... 

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