Multiple ligand binding sites cooperativity

The linkage of binding energy at multiple ligand sites is commonly referred to as cooperativity, and the free en-... 

Biochemists now know a great deal about the T and R states of hemoglobin, but much remains to be learned about how the T —> R transition occurs. Two models for the cooperative binding of ligands to proteins with multiple binding sites have greatly influenced thinking about this problem. 

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