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Multiple active site correction

Vigers, G. P., Rizzi, J. P. (2004) Multiple active site corrections for docking and virtual screening. /Med Chem 47, 80-89. [Pg.189]

Nitrogenase catalyzes the reduction of a number of substrates in addition to N2 and H+. Acetylene is reduced to ethylene, and nitrous oxide to dinitrogen, while azide undergoes reduction to N2 and NH3. In the last two cases the product N2 is not reduced further, implying that it is not in the correct binding position for reduction. The presence of multiple sites on the MoFe protein suggested by this observation is also supported by the non-competitive nature of the inhibition shown by some of these compounds. The reduction of acetylene has been used as a marker reaction for nitrogenase activity. [Pg.722]

See other pages where Multiple active site correction is mentioned: [Pg.47]    [Pg.151]    [Pg.91]    [Pg.8]    [Pg.196]    [Pg.92]    [Pg.47]    [Pg.151]    [Pg.91]    [Pg.8]    [Pg.196]    [Pg.92]    [Pg.72]    [Pg.139]    [Pg.670]    [Pg.246]    [Pg.72]    [Pg.295]    [Pg.299]    [Pg.107]    [Pg.415]    [Pg.67]    [Pg.154]    [Pg.251]    [Pg.449]    [Pg.155]    [Pg.8]    [Pg.190]    [Pg.280]    [Pg.149]    [Pg.213]    [Pg.32]    [Pg.1042]    [Pg.122]    [Pg.19]    [Pg.28]    [Pg.86]    [Pg.345]    [Pg.413]    [Pg.617]    [Pg.690]    [Pg.328]    [Pg.365]    [Pg.517]    [Pg.8]    [Pg.464]    [Pg.2222]    [Pg.52]    [Pg.593]    [Pg.18]    [Pg.87]    [Pg.72]    [Pg.75]   
See also in sourсe #XX -- [ Pg.196 ]



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