Multiple protein binding sites

Kinetic Analysis of Interactions Between Protein and a DNA Containing Multiple Protein Binding Sites... 

The HS7 region is composed of multiple factor binding sites some of these factors are ubiquitously expressed, whereas others are cell-specific factors, supporting the notion that the HS7 transcriptional activity is determined by a combinatorial control the combined action of tissue-restricted and ubiquitously expressed proteins. The HS7 regulatory region described in this report could either bring additional cellular... 

Metal storage proteins also form a variety of nitrosyl complexes. Metallothi-onein has been shown to form a low-spin complex with Fe and NO (Kennedy et al., 1993). Ferritin contains multiple iron binding sites capable of forming spectroscopically distinguishable nitrosyl complexes (Lee et al., 1994 LeBrun et al., 1993). 

One of the most important practical aspects of protein binding is the fact that drugs of similar or markedly dissimilar structure may compete for the same binding sites on the protein (7). Hence, multidrug therapy may lead to alteration in the plasma concentration and the rate of elimination of drugs, because of multiple competition for the plasma protein-binding sites. 

Klug, S.J., Huttenhofer, A. and Famulok, M. (1999) In vitro selection of RNA aptamers that bind special elongation factor Sel, a protein with multiple RNA-binding sites, reveals one major interaction domain at the carboxyl... 

Application of the LIS method to study the structure of biologically important macromolecules is fraught with some difficulties which are not usually encountered for small molecules. Poor spectral resolution, lack of resonance assignments and the availability of multiple lanthanide binding sites are some of the difficulties in probing the structures of macromolecules. Some LIS studies [101] have been reported for t-RNA. But most of the studies involve low molecular weight proteins which contain one or more lanthanide binding sites. Lanthanide ions bind in normal Ca(II) sites on proteins, such as amylases, ther-... 

Modeling of Multisite Fluorescence Quenching. A traditional multisite fluorescence quenching model using a Stem-Volmer approach has been developed and applied to quenching curves involving residual protein fluorescence (32). More recently, however, the multiple site model has been used to describe structural characteristics in diverse polymer environments (33-3f). The multisite Stem-Volmer model shown in equation 13 may be used to define multiple fluorescent binding sites present under one emission peak... 

Connick JH, Hanlon G, Roberts J, France L, Fox PK, Nicholson CD (1992) Multiple sigma binding sites in guinea-pig and rat brain membranes G-protein interactions. Br J Pharm 107 726-731... 

In this chapter we describe the spectroelectrochemical technique as it applies to nonheme and heme iron proteins containing single or multiple iron-binding sites, and as single protein or multiple subunit assemblies. In this discussion, we will address the influence of the following on the spectroelectrochemical... 

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