Moxifloxacin

In terms of pharmacokinetics, moxifloxacin has a high bioavailability, based on once-daily dosing of 400 mg, of 90% (Keating and Scott, 2004). The maximum plasma 

TABLE 4.4. MICgo Values of MXF Compared with Other Quinolones Against Bacteria Implicated in CART and Skin/Skin Structure Infections (Keating and Scott, 2004) 

Like the synthesis of levofloxacin, the coupling between side-chain 113 and the core 106 was achieved using mild conditions (Chava et al., 2005). Ethyl ester 106 was 

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Fig. 1. Esi-ms spectinm of aliuniniun-moxifloxacin solution. C, = 0.5 mmol dnr, C, =1.0 mmol dnU,...

The fluoroquinolones include ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), lome-floxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), and sparfloxacin (Zagain). 

Concurrent use of the fluoroquinolones with theophylline causes an increase in serum theophylline levels. When used concurrently with cimetidine, the cimetidine may interfere with the elimination of the fluoroquinolones. Use of the fluoroquinolones with an oral anticoagulant may cause an increase in the effects of the oral coagulant. Administration of the fluoroquinolones with antacids, iron salts, or zinc will decrease absorption of the fluoroquinolones. There is a risk of seizures if fluoroquinolones are given with the NSAIDs. There is a risk of severe cardiac arrhythmias when the fluoroquinolones gatifloxacin and moxifloxacin are administered with drains that increase the QT interval (eg, quini-dine, procainamide, amiodarone, and sotalol). 

Ci,)Hi,N503S2 37539-03-0) see Cefatrizine 2-amino-2, 4,4 trichlorodiphenyJ ether (C12HXCI3NO 56966-52-6) see Triclosan 2-amino-3,5,6-trifluoro-4-methoxybenzonitriIe (CXH5F3N2O 114214-46-9) see Moxifloxacin hydrochloride... 

C7H()N 100-46-9) see Amosulalol Bamidipine Beclamide Benperidol Betanidine Biotin Cisapride Dilevalol Guanoxan Moxifloxacin hydrochloride NebivOlol Nialamide Reproterol Sparfloxacin Sulbentine Viloxazine benzylamine hydrochloride (C7H,()C1N 3287-99-8) see Benzyl mustard oil 2-benzylaminoethanol... 

C]()Hi,N02S 3054-01-1) see Bucillamine ( )-cis-8-benzyl-2,8-diazabicyclo[4.3.0]nonane (C14H20N2 161594-54-3) see Moxifloxacin hydrochloride... 

C3H7N 765-30-0) see Abacavir Ciprofloxacin Grepafloxacin Moxifloxacin hydrochloride Nevirapine Sparfloxacin... 

C14H20N2 151213-39-7) see Moxifloxacin hydrochloride octahydro 2/f quinolizine-3-carboxylic acid ethyl ester... 

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... 

Complicated exacerbation FEV, less than 50% predicted Comorbid cardiac disease Greater than or equal to 3 exacerbations per year Antibiotic therapy in the previous 3 months Above organisms plus drug-resistant pneumococci, P-lactamase-producing H. influenzae and M. catarrhalis, Escherichia coli, Proteus spp., Enterobacter spp., Klebsiella pneumoniae Oral P-Lactam/P-Iactamase inhibitor (amoxicil 1 i n-clavulanate) Fluoroquinolone with enhanced pneumococcal activity (levofloxacin, gemifloxacin, moxifloxacin) Intravenous P-Iactam/P-Iactamase inhibitor (ampicillin-sulbactam) Second- or third-generation cephalosporin (cefuroxime, ceftriaxone) Fluoroquinolone with enhanced pneumococcal activity (levofloxacin, moxifloxacin)... 

Because an infection slows the healing of a corneal abrasion, prophylactic antibiotics are often used. Studies on the efficacy of this are mixed. Discontinue the use of contact lenses until the abrasion is healed and the antibiotic course complete. In contact lens wearers, choose an antibiotic that covers Pseudomonas aeruginosa, like gentamicin ointment or solution or a fluoroquinolone.3 Antibiotic resistance is an increasing problem. Resistance occurs primarily with older antibiotics, but has been reported for fluoroquinolones as well. Two newer fluoroquinolones, gatifloxacin and moxifloxacin, do not yet have reports of resistance. These agents are more expensive.6... 

Penicillin MIC 0.1-1 mg/L Standard Therapy Ceftriaxone or cefotaxime Alternative Therapies Moxifloxacin 400 mg IV every Nausea/vomiting/diarrhea, dizziness, ... 

Pseudomonas Moxifloxacin or meropenem orTMP-SMX or ampicillin Standard Therapy seizures At least 21 days... 

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