Pantoprazole sodium

CjjH(,F2N20S 97963-62-7) see Pantoprazole sodium 4-(difluoromethoxy)-2-nitrobenzenamine (C7H(,F2N203, 97963-76-3) see Pantoprazole sodium A -[4-(difluoromethoxy)phenyl]acetamide (0)HyF2N02 22236-11-9) see Pantoprazole sodium 2-(difluoromethoxy)-l,l,l-trifiuoroethane (C3H3F5O 1885-48-9) see Isoflurane (5)-9,10-difluoro-3-methyI-7-oxo-2,3-dihydro-7/f-pyrb do[l,23-d ]-Iy4 benzoxazine-6-carboxylic acid (C,3Hyp2N04 100986-89-H) see Levofloxacin... 

C2jH27N303 71987-57-0) see Oxypertine 3,4 dimethoxy-2-methylpy ridine 1 -oxide (CjHiiNO, 72830-07-0) see Pantoprazole sodium... 

C3H5KOS2 140-89-6) see Cefaclor Omeprazole Pantoprazole sodium Protizinic acid Pyritinol potassium hexachloroplatinate(IV)... 

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... 

D Eberle, RP Hummel, R Kuhn. Chiral resolution of pantoprazole sodium and related sulfoxides by complex formation with bovine serum albumin in capillary electrophoresis. J Chromatogr A 759 185—192, 1997. 

Proton pump inhibitors lansoprazole omeprazole magnesium pantoprazole sodium rabeprazole sodium... 

Salama et al. [34] developed and validated a spectrophotometric method for the determination of omeprazole and pantoprazole sodium via their metal chelates. The procedures were based on the formation of 2 1 chelates of both drugs with different metal ions. The colored chelates of omeprazole in ethanol were determined spectrophotometrically at 411, 339, and 523 ran using iron(III), chromium(III), and cobalt(II), respectively. Regression analysis of Beer s plots showed good correlation in the concentration ranges 15-95, 10-60, and 15-150 /ig/ ml of pure omeprazole using iron(III), chromium(III), and cobalt(II), respectively. 

The calculated water content of pantoprazole sodium sesquihydrate is 6.25%. 

Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor, and was developed for the treatment of acid-related gastrointestinal disorders. As with other drugs of its class (e. g. omeprazol or lansoprazole), pantoprazole reduces gastric acid secretion through inhibition of the portion on the gastric parietal cell. In combination with other drugs, pantoprazole can be used for the initial treatment of H. Pylori infection [1],... 

The route of synthesis of pantoprazole sodium, as described in US patent 4758579 (1988), is as follows. 2-chloromethyl-3,4 dimethoxypyridinium hydrochloride(I) is condensed with 5-difluoromethoxy-2-mercapto-benzimidazole(H) in ethanolic sodium hydroxide solution to yield 5-(difluoromethoxy)-2-(((3,4-dimethoxypyrolidine-2-yl) methyl) thio)-l/7-benzimidazole)(III). This compound is oxidized during reaction with m-chloroperbenzoic acid in methylene chloride, yielding pantoprazole base (IV). Further reaction with aqueous caustic soda solution gives pantoprazole sodium, which is then purified by crystallization from methanol. The various steps of this synthesis are illustrated in Scheme 1. 

The solubility of pantoprazole sodium has been studied in a variety of different solvents ... 

The partition coefficient of pantoprazole sodium between n-octanol and water was determined at room temperature using a spectrophotometric procedure, and was found to be 1.3. 

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