Moxifloxacin Itraconazole

Azalides azithromycin Azoles fluconazole, itraconazole, ketoconazole, and voriconazole Macrolides erythromycin, clarithromycin Protease inhibitors amprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, and saquinavir Quinolones ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin. 

Significant drug interactions with theophylline [268], itraconazole [269], warfarin, yS-acetyldigoxin, ranitidine, probenecid and oral contraceptives have not been reported with moxifloxacin [12,237]. 

Stass H, et al. Lack of influence of itraconazole (ITR) on moxifloxacin (MFX) pharmacokinetics in healthy male subjects. In 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract No. 2270. Toronto, 2000. 

Clinically important, potentially hazardous interactions with alfentanil, aminophylline, amisulpride, amoxicillin, ampicillin, anticonvulsants, astemizole, atorvastatin, benzodiazepines, bromocriptine, buprenorphine, bupropion, carbamazepine, cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine, cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem, disopyramide, enoxacin, eplerenone, ergotamine, eszopiclone, everolimus, fluconazole, fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin, lorazepam, lovastatin, methadone, methylprednisolone, methysergide, midazolam, mizolastine, moxifloxacin, nitrazepam, norfloxacin, ofloxacin, paroxetine, pimozide, pravastatin, quinolones, ranolazine, repaglinide, rupatadine, sertraline, sildenafil, simvastatin, sparfloxacin, sulpiride, tacrolimus, terfenadine, triazolam, troleandomycin, vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem, zuclopenthixol... 

Clinically important, potentially hazardous interactions with amiodarone, astemizole, bepridil, carbamazepine, chloroquine, cisapride, clarithromycin, dihydroergotamine, disopyramide, ergotamine, grapefruit juice, halofantrine, haloperidol, itraconazole, ketoconazole, methadone, moxifloxacin, phenobarbital, phenytoin, pimozide, procainamide, quinidine, rifampicin, ritonavir, sotalol, St John s wort, telithromycin, terfenadine, voriconazole... 

A study in healthy subjects found that itraconazole 200 mg daily for 9 days did not affect the pharmacokinetics of a single 200-mg dose of moxifloxacin given on day 7. No clinically relevant changes were found in the pharmacokinetics of itraconazole. No special precautions would seem to be necessary during concurrent use. 

Stass H, Nagelschmitz J, Moeller J-G, Delesen. Pharmacokinetics of moxifloxacin are not influenced by a 7-day pre-treatment with 200 mg oral itraconazole given once a day in healfliy subjects. Int J Clin Pharmacol Ther (2004) 42,23-9. 

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