Moxifloxacin adverse effects

The most common adverse effects of moxifloxacin are gastrointestinal disturbances (nausea, diarrhea), which are usually mild to moderate in intensity and do not force patients to discontinue treatment (19,20). The frequency of nausea and vomiting is higher than the frequency of diarrhea and abdominal pain (21). Moxifloxacin caused nausea in 7.2% and diarrhea in 5.7% of patients (19). 

In an analysis of cases of torsade de pointes associated with fluoroquinolones on the FDA Adverse Events Reporting System database, two cases of torsade de pointes were noted in patients taking a fluoroquinolone with sotalol (there were 37 cases identified, and 19 occurred in patients also taking other drugs known to prolong the QT interval). Sotalol has class III antiarrhythmic effects and prolongs the QT interval, and this could be additive with the effects of quinolones that prolong the QT interval (e.g. gat-ifloxacin, moxifloxacin, sparfloxacin, see Table 9.2 , (p.257)). The... 

A meta-analysis of the cardiac effects of moxiflocaxin was carried out. Moxifloxacin-received 14981 subjects were included in the analysis. The most common adverse events were those commonly described with moxifloxacin use and included diarrhoea, dizziness, vomiting, increased lipase, increased GGT and rash. Prolonged QTc (corrected QT) ocoured in 72 patients and cardiac arrest in 18. No events were significantly greater than a standard comparator in this study [55 ]. 

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