Nausea moxifloxacin

Penicillin MIC 0.1-1 mg/L Standard Therapy Ceftriaxone or cefotaxime Alternative Therapies Moxifloxacin 400 mg IV every Nausea/vomiting/diarrhea, dizziness, ... 

Fluoroquinolones are extremely well tolerated. The most common effects are nausea, vomiting, and diarrhea. Occasionally, headache, dizziness, insomnia, skin rash, or abnormal liver function tests develop. Photosensitivity has been reported with lomefloxacin and pefloxacin. QTC prolongation may occur with gatifloxacin, levofloxacin, gemifloxacin, and moxifloxacin, which should be avoided or used with caution in patients with known QTC interval prolongation or uncorrected... 

In an open, randomized, crossover study, the absolute systemic availability of a single 100 mg dose of moxifloxacin was 0.92 in 10 healthy men (mean age 29 years) (8). There was no evidence of active tubular secretion. Both the oral and intravenous formulations were well tolerated, with five reported possible or probable drug-related adverse events, including headache, nausea, and localized urticaria. 

In a prospective, uncontrolled, unbhnded, phase III trial in 254 patients with community-acquired pneumonia diagnosed by culture or serologically, moxifloxacin (400 mg/day orally for 10 days) produced a bacteriological response of 91% (9). Drug-related adverse events were reported in 33% of patients nausea (9%), diarrhea (6%), and dizziness (4%) were the most common adverse events. 

Most adverse events, possibly or probably related to moxifloxacin, were generally mild or moderate and were mostly related to the digestive system diarrhea, nausea, and abdominal pain with 200 mg/day diarrhea, liver function abnormalities, and nausea with 400 mg /day. The drugs were withdrawn because of adverse events in seven of 229 patients taking 200 mg/day, and 11 of 224 taking 400 mg/day. 

The most common adverse effects of moxifloxacin are gastrointestinal disturbances (nausea, diarrhea), which are usually mild to moderate in intensity and do not force patients to discontinue treatment (19,20). The frequency of nausea and vomiting is higher than the frequency of diarrhea and abdominal pain (21). Moxifloxacin caused nausea in 7.2% and diarrhea in 5.7% of patients (19). 

Comparative studies Oral moxifloxacin for 2 weeks has been compared with levofloxacin -I- metronidazole in 460 women with uncomplicated pelvic inflammatory disease [41 ]. Clinical and bacteriological efficacies were comparable nausea (19% and 23%) and dizziness (16% and 15%) in the moxifloxacin and comparator groups were the most common adverse events. One moxifloxacin-treated subject developed Stevens—Johnson syndrome. 

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