Sulbactam-ampicillin

Complicated exacerbation FEV, less than 50% predicted Comorbid cardiac disease Greater than or equal to 3 exacerbations per year Antibiotic therapy in the previous 3 months Above organisms plus drug-resistant pneumococci, P-lactamase-producing H. influenzae and M. catarrhalis, Escherichia coli, Proteus spp., Enterobacter spp., Klebsiella pneumoniae Oral P-Lactam/P-Iactamase inhibitor (amoxicil 1 i n-clavulanate) Fluoroquinolone with enhanced pneumococcal activity (levofloxacin, gemifloxacin, moxifloxacin) Intravenous P-Iactam/P-Iactamase inhibitor (ampicillin-sulbactam) Second- or third-generation cephalosporin (cefuroxime, ceftriaxone) Fluoroquinolone with enhanced pneumococcal activity (levofloxacin, moxifloxacin)... 

If a patient aspirates his or her oral contents and pneumonia develops, then anaerobes and Streptococcus spp. are the primary pathogens. Antibiotics active against these organisms include penicillin G, ampicillin/sulbactam, clindamycin, and metronidazole. 

If the child is not admitted to the ICU, then the CDC recommends the use of intravenous cefuroxime, cefotaxime, ceftriaxone, or ampicillin-sulbactam plus a macrolide or azalide. If... 

Injection drug use MSSA GAS Gram-negatives Anaerobes CA-MRSAd Amoxicillin-clavulanate 500 mg every 8 hours Fluoroquinolone + clindamycin 300 mg every 6 hours TMP-SMX DS 1-2 tabs every 12 hours + clindamycin 300 mg every 6 hours Ampicillin-sulbactam 3 g every 6 hours Piperacillin-tazobactam 3.375 g every 6 hours Ceftriaxone 1 g daily + clindamycin 600 mg every 8 hours Ertapenem 1 g daily... 

If the wound is associated with significant cellulitis and edema, systemic signs of infection, or possible joint or bone involvement, hospitalization and IV antibiotics (typically ampicillin-sulbactam 3 g IV every 6 hours) should be initiated. Bone and joint infections will require longer durations of therapy of up to 6 weeks.44... 

Normal or inflamed Antianaerobic cephalosporins3 (discontinued immediately postoperation) 1. Ampicillin-sulbactam... 

Pelvic Inflammatory Disease Cefotetan or cefoxitin with doxycycline 1. Clindamycin with gentamicin 2. Ampicillin-sulbactam with doxycycline 3. Ciprofloxacin with doxycycline and metronidazole... 

Levofloxacin 500 mg IV every 24 hours with or without metronidazole 500 mg IV every 8 hours Ampicillin-sulbactam, 3 g IV every 6 hours and doxycycline 100 mg PO or IV every 12 hours Oral... 

Community-acquired pneumonia Health care-associated, ventilator-asociated, or nosocomial pneumonia (Early onset no risk factors for MDR pathogens) Third-generation cephalosporin plus a macrolide or doxycycline Third-generation cephalosporin OR Fluoroquinolone OR Ampicillin-sulbactam OR Ertapenem... 

Intra-abdominal Ampicillin-sulbactam OR Fluoroquinolone + metronidazole Piperacillin-tazobactam OR Imipenem or meropenem OR Cefepime plus metronidazole OR Ciprofloxacin or levofloxacin plus metronidazole... 

Treatment for septic patients with hospital-acquired, ventilator-acquired, and health care-associated pneumonia is dependent on risk factors for multi-drug resistant (MDR) organisms (Fig. 79-2). Recommended treatment for patients with no MDR risk factors are third-generation cephalosporins, fluoroquinolones, ampicillin-sulbactam, or ertapenem (see Table 79-3).35 Recommended treatment for patients with MDR risk factors are P-lactam/p-lactamase inhibitors (piperacillin-tazobactam), antipseudomonal cephalosporin, or carbapenem, plus an aminoglycoside, plus vancomycin or linezolid (see Table 79-3).35 If an aminoglycoside is undesirable, a antipseudomonal fluoroquinolone may be utilized with a P-lactam/p-lactamase inhibitor. 

Cesarean section Cefazolin 1-2 g IV, ampicillin/sulbactam 3 g IV See hysterectomy... 

Ampicillin + sulbactam major i minimal i PMC patients C. difficile correlated with 31, 35, 84 38... 

GS-Lactamase inhibitor combination-IV ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin-clavulanate po amoxicillin-clavulanate. Cefoxitin. 

In addition to isolates with high-level aminoglycoside resistance, /3-lacta-mase-producing enterococci (especially Enterococcus faecium) are increasingly reported. If these organisms are discovered, use of vancomycin or ampicillin-sulbactam in combination with gentamicin should be considered. 

Ampicillin-sulbactam Tica rcillin-clavulanate Carbapenems... 

Cefotaxime, ceftriaxone, ampicillin-sulbactam, or ertapenem ertapenem was recently approved for such use (in once-daily parenteral treatment) but little experience is available. 

Treatment options for patients requiring intravenous therapy include /J-lactam-/3-lactamase inhibitors (ampicillin-sulbactam or piperacillin-tazobactam), second-generation cephalosporins with antianaerobic activity (cefoxitin), and carbapenems. 

Aninoglycosides Gentamicin Tobramycin Amikacin Penicillins Ampicillin Ampicillin-sulbactam Ticarcillin-davulanate Piperacillin-tazobactam Cephalosporins, first-, second-, and third-generation... 

Ampicillin/Sulbactam Dosage Guide For Patients With Renai... 

The safety and efficacy of ampicillin/sulbactam sodium has not been established for pediatric patients for intra-abdominal infections. CARBENICILLININDANYL SODIUM ... 

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