Monocytes, differentiation

Verres T, Stahl M, Melchers I, Luttmann W, Muller-Quernheim J, Zissel G IL-lO-producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients. J Allergy Clin Immunol 2007 119 464-471. 

Recruited blood monocytes encountering local elevated levels of Ap peptide would then refold the Ap into a fibrillar conformation, thus forming the core of an NP adjacent to a blood vessel [24]. These plaque-bound monocytes differentiate into macrophages and mount an aberrant "wound response" through the release of neurotrophic and chemotactic agents, inducing an inappropriate ectopic sprouting response toward the... 

Hayashi, S., et. al., Expression of Ah receptor (TCDD receptor) during human monocytic differentiation, Carcinogenesis. 16, 1403, 1995. 

Stone RM, Sariban E, Pettit GR, Kufe DW (1988) Biyostatin 1 activates PKC and induces monocytic differentiation of HL60 cells. Blood 72 208-213. 

Monocytes Differentiate to macrophages, which phagocytose damaged cells and bacteria 4X10 3-6d... 

HV188 Tamagawa K., S. Fukushima, M. Kobori, H. Shinmoto, and T. Tsushida. Proanthocyanidins from barley bran potentiate retinoic acid-induced granulocytic and sodium butyrate-induced monocytic differentiation of... 

PPAR is a nuclear receptor-transcription factor and is ligand-dependent and expressed in several tissues. It is initially involved in adipocyte differentiation and fatty acid synthesis. Fatty acid and eicosanoids bind to PPAR and regulate transcription. PPAR activation inhibits monocyte differentiation and expression of several pro-inflammatory genes such as iNOS, TNF, etc. PPAR activation inhibits tumor cell proliferation (epithelial, colon, prostate). PPAR is involved in angiogenesis. 

Wu, S, Palese, T, Mishra, OP, Delivoria-Papadopoulos, M and De Luca, F, 2004, Effects ofCa2+ sensing receptor activation in the growth plate, Faseb J 18 143-145 Yamaguchi, T, Ye, C, Chattopadhyay, N, Sanders, JL, Vassilev, PM and Brown, EM, 2000, Enhanced expression of extracellular calcium sensing receptor in monocyte-differentiated versus undifferentiated... 

Gelebart, P., Martin, V., Enouf, J., and Papp, B., 2003, Identification of a new SERCA2 splice variant regulated during monocytic differentiation. Biochem Biophys Res Commun, 303 676-84. 

S. Vitols, G. Gahrton, A. Ost and C. Peterson, Elevated low density lipoprotein receptor activity in leukemic cells with monocytic differentiation, Blood 63 (1984) 1186-1193. 

Two major classes of WBCs are involved in removing invading microorganisms by a process of phagocytosis. These are polymorphonuclear leukocytes and mononuclear phagocytes, or monocytes. In tissues, monocytes differentiate into macrophages and, in the brain, into microglia... 

Fraser DJ, Brandt TL, Kroll DJ. 1995. Topoisomerase Ila promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells. Mol Pharmacol 47 696-706. 

Hayden, J.M., Brachova, L., Higgins, K., Obermiller, L., Sevanian, A., Khandrika, S., Reaven, P.D. 2002. Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. J. Lipid Res. 43, 26-35. 

The polyphenol extract from the barley bran (BPE) induced the differentiation of human promyelocytic leukemia HL-60 cells, based on the expression of the differentiation markers such as nitro blue tetrazolium (NBT) reducing activity and a-naphthyl butyrate esterase activity. Prodelphini-din B-3, Tl, T2, and T3 induced 26-40% NBT-positive cells and 22-32% a-naphthyl butyrate esterase-positive cells. Proanthocyanidins might potentiate the retinoic acid (all-frarcs-retinoic acid)-induced granulocytic differentiation and sodium butyrate-induced monocytic differentiation in the HL-60 cells [101]. 

Bar-Shavit Z, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, and Kahn AJ (1983) Indnction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proceedings of the National Academy of Sciences of the USA 80,5907-11. 

Koschmieder S, Agrawal S, Radomska HS, Huettner CS, Tenen DG, Ottmann OG, Berdel WE, Serve HE, Muller-Tidow C. Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation. Int. Oneok 2007 30 349-355. 

Vitamin K2 (menaquinone) represents a series of compounds in which the phytyl side chain of phytonadione has been replaced by a side chain built up of 1-14 isoprenyl units. It has been reported that vitamin K2 with four isoprenyl units (4) induced the monocytic differentiation of human myeloid leukemia cell lines [58], or apoptosis in isolated osteoclast [59] and human ovary cancer cells [60]. We have recently found that vitamin K2 derivatives (1-3) induced some tumor-specific cytotoxicity and non-apoptotic cell death in oral carcinoma [61]. As an extension of the search for tumor-specific substances targeted against human oral squamous, hepatocellular carcinoma, and promyelocytic leukemia cell lines, we investigated the QSAR of seven vitamin K2 derivatives (1-7) (Fig. 18), by conventional and recent techniques of computation chemistry, such as the concept of absolute hardness [ 16-18]. 

Monocytes differentiate into macrophages during ceU culture and lose their ability to produce IFNa when challenged with HIV-1. However, these cells remain capable of producing IFNa in response to other stimuli, suggesting that as monocytes differentiate into macrophages, they selectively lose their ability to produce IFNa through the double-stranded RNA (dsRNA) independent mechanism. ... 

Francis ML, Fan XS, Meltzer MS. Loss ability to produce IFN-a in response to HIV-1 as monocytes differentiate into macrophages. Induction through a mechanism independent of double-stranded RNA. J Immunol 1996 156 2481-7. 

F. Liang, V. Seyrantepe, K. Landry, R. Ahmad, A. Ahmad, N. M. Stamatos, and A. V. Pshezhetsky, Monocyte differentiation up-regulates the expression of the lysosomal sialidase, neul, and triggers its targeting to the plasma membrane via major histocompatibility complex class Il-positive compartments, J. Biol. Chem., 281 (2006) 27526-27538. 

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