Ca2+-sensing Receptor

Ca2+ sensing receptor, a member of G-protein coupled receptors, is composed of seven transmembrane spanning domains. The extracellular domain contains clusters of negatively charged amino acids sensing even small fluctuations of extracellular calcium. Mutations in this receptor cause inheritable hypo- and hypercalcemic syndromes. 

Ca2+-sensing Receptor Calpains Protein Phosphates S100 Proteins... 

Hu J, Spiegel AM (2003) Naturally occurring mutations of the extracellular Ca2+-sensing receptor implications for its structure and function. Trends Endocrinol Metab 14 282-288... 

A class of drugs that blocks the activation of the Ca2+-sensing receptor by extracellular Ca2+. 

A class of allosteric activators of the Ca2+-sensing receptor that sensitizes the receptor to extracellular calcium and acts only in the presence but not in the absence of calcium. Calcimimetics can be used to treat various forms of hyperparathyroidism, although they are only approved for use in patients with end stage renal disease receiving dialysis treatment. 

Naito T., Saito Y Yamamoto J., Nozaki Y., et al. (1998). Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu. Proc Natl Acad Sci USA 95, 5178-5181. 

Conigrave, AD, Quinn, SJ and Brown, EM, 2000, L-amino acid sensing by the extracellular Ca2+-sensing receptor, Proc Natl Acad Sci U S A 97 4814 1819... 

Handlogten, ME, Huang, C, Shiraishi, N, Awata, H and Miller, RT, 2001, The Ca2+-sensing receptor... 

Schwarz, P, Larsen, NE, Lonborg Friis, IM, Lillquist, K, Brown, EM and Gammeltoft, S, 2000, Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism associated with mutations in the human Ca2+ -sensing receptor gene in three Danish families, Scand J Clin Lab Invest 60 221-227 Schwarz, P, Sorensen, HA, McNair, P and Transbol, I, 1993, Cica-clamp technique a method for quantifying parathyroid hormone secretion a sequential citrate and calcium clamp study, Eur J Clin Invest 23 546-553... 

Shimizu, T., Morishima, S. and Okada, Y., 2000, Ca2+-sensing receptor-mediated regulation of volume-sensitive Cl- channels in human epithelial cells. J Physiol 528, 457-72. 

Adebanjo OA, Igietseme J, Huang CL-H, Zaidi, M. 1998a. The effect of extracellularly applied divalent cations on cytosolic Ca2+ in murine leydig cells evidence for a Ca2+-sensing receptor. Journal of Physiology 513 399-410. 

Gama L, Baxendale-Cox LM, Breitwieser GE. 1997. Ca2+-sensing receptors in intestinal epithelium. Am J Physiol 273 Cl 168-75. 

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