Mesenchymal malignant

Although angiosarcoma is a rare hepatic malignancy and accounts for less than 2% of all primary liver neoplasms, it is the most common mesenchymal malignancy in the liver in adults. Primary hepatic angiosarcoma is occurring more frequently than fibrosarcoma, malignant fibrous histiocytoma and leiomyosarcoma (Buetow et al. 1997). 

Dibromoethane is a potent carcinogen in rats and mice, causing malignant and benign neoplasms of epithelial and mesenchymal origin in multiple organ systems when administered by inhalation, oral, or dermal routes. Cancer was also induced at initial point of contact with... 

In the NTP (1986) study, male mice had marginally increased incidences of hepatocellular tumors and mesenchymal tumors of the integumentary system at 500 mg/kg/day and of malignant lymphomas at 250 mg/kg/day. NTP (1986) considered this evidence to be equivocal because the study showed marginal increases in neoplasms related to isophorone exposure. The doses of 250 and 500 mg/kg/day are indicated in Table 2-2 and Figure 2-2 as CELs for carcinogenicity in mice. There was no evidence of carcinogenicity in female rats or mice. 

Lazarus,H. M., , .N.,Devine,S. M.,et al. (2005), Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients, Biol. Blood Marrow Transplant., 11(5), 389-398. 

Eriksson M, Hardell L, Berg NO, et al. 1979. Case-control study on malignant mesenchymal tumors of the soft tissue and exposure to chemical substances. Lakartidningen 76 3872-3875. 

Alterations in the liver parenchyma as a result of foreign substances are characterized by several parenchymal, mesenchymal and vascular basic reactions as well as by benign or malignant neoplasia. It seems reasonable to classify the morphological findings in accordance with the acuteness and chronicity of their occurrence - bearing in mind all fundamental and individual reservations with regard to their systematization, (s. tab. 29.2). 

Epithelioid haemangioendothelioma is a malignant mesenchymal tumour, which was first described in the liver by s.w. Weiss et al. in 1982. (s. tab. 37.1) It is probably a variant of haemangiosarcoma, but with a much better prognosis (approx. 50% of patients survive for more than 5 years). This multifocular, vascularized tumour with low-grade malignancy can affect the liver... 

Suarez A, McDowell El, NIaudet P, Comoy E, and Flamant F. Long term follow up of Ifosfamide renal toxicity in children treated for malignant mesenchymal tumors an International society of pediatric oncology report. J Clin Oncol, 9 2177-2182,1991... 

A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. 

Most neoplasms are classified and named based on (1) the cell or tissue of origin and (2) benign or malignant growth characteristics. There are two basic cell types from which neoplasms may originate mesenchymal cells and epithelial cells (Figure 2). Mesenchymal pertains to mesenchyma (embryonic... 

Note-, -oma, swelling sarc-, malignant neoplasm of mesenchymal origin carcin-, malignant neoplasm of epithelial origin. 

Borovic S, Cipak A, Meinitzer A, et al. Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells. Redox Rep2007, 12(1) 50 4. 

The liver is host to a wide variety of both benign and malignant primary tumors. It is also the second most common site of metastases metastatic tumors account for 90% to 95% of all hepatic malignancies. The primary tumors may arise from many cell lines in the liver but most commonly from parenchymal and biliary epithelial cells and mesenchymal cells (Table 47-10). The two most important primary liver tumors are HCC and cholangiocarcinoma. 

Interspecific Xiphophorus hybrids known to produce heritable melanoma and other forms of cancer have thus become a well-established model in which the underlying molecular mechanisms are starting to be elucidated. In addition to the hereditary melanoma model, other hybrids are available that develop defined epithelial, mesenchymal and neuronal neoplasia following treatment with specific carcinogens these all offer the opportunity to study the molecular mechanisms responsible for the malignant phenotype obtained. 

Over four decades ago, it was first reported that carcinogens in vitro could induce malignant transformation in normal cultured mesenchymal cells (Berwald and Sachs... 

Malignant mesenchymal neoplasms—various types No Bruner et al. (2001), Evans et al. (1997), ICRT (1993b)... 

In reference to still other mesenchymal neoplasms, experience since the 1990s has shown that under some circumstances, selected tumors that are typically devoid of keratins may synthesize those IFPs in an aberrant fashion (Table 4.2). Indeed, at this point, virtually all sarcoma morphotypes have been reported to show this potential. Nevertheless, we would like to emphasize that aberrant keratin reactivity is most common in a narrow spectrum of malignant mesenchymal neoplasms that are studied under usual diagnostic conditions, principally leiomyosarcoma (LMS), malignant peripheral... 

---