Identical sibling

Beatty PG, Glift RA, Mickelson EM, Nisperos BB, Flournoy N, Martin PJ, Sanders JE, Stewart P, Buckner GD, Storb R. Marrow transplantation from related donors other than HLA identical siblings. N Engl J Med. 1985 Sep 26 313(13) 765 71. 

Lazarus,H. M., , .N.,Devine,S. M.,et al. (2005), Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients, Biol. Blood Marrow Transplant., 11(5), 389-398. 

Marrow transplantation from related donors other than HLA-identical siblings Beatty, P.G., Clift, R.A., Mickelson, E.M., Nisperos, B.B., Flournoy, N., Martin, P.J.,... 

Polymorphisms in cytokine genes can influence immune responses, inflammation, and tissue injury and may affect the outcome of hematopoietic stem cell transplantation. Among recipients of hematopoietic cells from an HLA-identical sibling, the IL-10-592A allele seems to be a marker... 

While the HLA loci can be used to study the engraftment of transplanted hematopoietic stem cells (see later in this chapter), other more convenient loci are genotyped for this purpose. These other loci are essential when the transplant donor recipient pair are HLA-identical siblings or allele-matched unrelated individuals. 

Ruutu T, Volin L, Parkkli T, et al. Cyclosporine, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of graft-versus-host disease in bone marrow transplantation from HLA-identical sibling donor A prospective randomized study. Blood 2000 96 2391-2398. 

ULA-identical sibling bone marrow transplantation. Blood 1998 92 2303-2314. 

Elmaagacli AH, Peceny R, Steckel N, et al. Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic phase chronic myeloid leukemia. Blood 2003 101 446-453. 

Products of what is now known as the HLA class II region were originally detected through the use of the mixed lymphocyte culture (MLC) assay (Bl, B3). This test uses the principle that when lymphocytes from genetically dissimilar individuals are mixed under appropriate cell culture conditions, the lymphocytes of one individual will stimulate those of the other to reproduce and form blast cells. The finding that lymphocytes from HLA-A and HLA-B identical siblings did not stimulate each other in the MLC, whereas lymphocytes from HLA-A and HLA-B identical Individuals did, suggested that the MLC reaction is related to the HLA system but is controlled by a locus separate from HLA-A and HLA-B (Y3). This... 

Since the treatment of severe GVHD is often unsuccessful, the most appropriate strategy is primary prevention of the condition. For this reason, most bone marrow transplantation to date has used HLA-identical siblings as donors. In Western countries, however, only about 30% of patients have an HLA-matched sibling... 

On the basis of these findings it may be concluded that transplantation from a partially matched relative has a distinct role as a treatment option when a fully matched relative is not available. But what is the solution for patients who have neither an HLA-identical sibling donor nor another relative with a one antigen mismatch Many centers have begun to look outside the patients immediate families for the answer. 

BIT Betuel, H., Pouteil-Noble, C., Freidel, A. C., Touraine, J. L., Gebuhrer, L., Dubernard, J. M., and Traeger, J. Rejection episodes after kidney transplantation between HLA-identical siblings. Transplant. Proc. 17, 2287-2291 (1985). 

D7. Descamps, B., Hinglais, N., and Crosnier, J. Renal transplantation between 33 HL-A-identical siblings. Transplant. Proc. 5, 231-236 (1973). 

Gluckman E, Broxmeyer H A, Auerbach A D, et al. (1989). Hematopoietic reconstitution in a patient with Fanconi s anemia by means of umbilical-cord blood from an HLA-identical sibling. N. Engl. J. Med. 321 1174-1178. 

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