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Malignant neoplasia

Persistent effects do not resolve, and may even become more severe after removal from the source of exposure. They can occur as a consequence of acute or repeated-exposure conditions. Thus, the use of the term persistent should be clearly differentiated from the implication of the use of the description of an effect as chronic. It should be noted, however, that some chronic effects may be persistent an example is malignant neoplasia. [Pg.227]

Ulcerative or inflammatory lesions may affect the physiology of the small and large intestine. Ulcer formation entails a circumscribed loss of tissue from the surface of an organ, which results from necrosis following cell destruction by chemicals and the like, or by restriction of the blood supply. Ulcers are among the most common and important lesions. Those that do not penetrate the muscularis mucosa are called erosions. Ulcerative conditions in humans must be differentiated from malignant ulcers, which are associated with neoplasia. Among... [Pg.159]

Stanulla M, Schaeffeler E, Moricke A et al. Thiopurine methyltransferase genotype is not a risk factor for secondary malignant neoplasias after treatment for childhood acute lymphoblastic leukemia on Berlin FrankfurtMunster protocols. Blood 2006 108 48a. [Pg.201]

Warner M, Saji S, Gustafsson JA. 2000. The normal and malignant mammary gland A fresh look with ER beta onboard. J Mammary Gland Biol Neoplasia 5 289-294. [Pg.134]

Products that may have the potential to stimulate growth or induce proliferation or clonal expansion of cell types, in particular, transformed cells, all processes that may eventually lead to neoplasia should be evaluated with respect to receptor expression in various malignant and normal human cells that are relevant to the patient population under study [27], In such cases normal human cell lines and multiple human cancer cell lines expressing the relevant receptor, as well as primary cells derived from human tumor explants, should be used for in vitro assessment. When in vitro data demonstrate enhanced growth, further studies in relevant in vivo xenograft animal models with receptor expressing tumor cell lines may be needed. In addition incorporation of sensitive indexes of cellular proliferation in long-term repeat-dose toxicity studies may provide useful information. [Pg.413]

Interferons (IFN) are glycoproteins that, among other products, are released from virus-infected cells. In neighboring cells, interferon stimulates the production of antiviral proteins. These inhibit the synthesis of viral proteins by (preferential) destruction of viral DNA or by suppressing its translation. Interferons are not directed against a specific virus, but have a broad spectrum of antiviral action that is, however, species-specific. Thus, interferon for use in humans must be obtained from cells of human origin, such as leukocytes (IFN-a), fibroblasts (IFN-p), or lymphocytes (IFN-y). Interferons are used in the treatment of certain viral diseases, as well as malignant neoplasias and autoimmune diseases e.g., IFN-a for the treatment of chronic hepatitis C and hairy cell leukemia and IFN-p in severe herpes virus infections and multiple sclerosis. [Pg.286]

Uricolytics. Nonprimates are able, via the enzyme urate oxidase, to metabolize uric acid to allantoin, a product with better water solubility and faster renal elimination. Ras-buricase, a recombinant urate oxidase, can be given by infusion in patients with malignant neoplasias, in whom chemotherapy is liable to generate a massive amount of uric acid. [Pg.326]


See other pages where Malignant neoplasia is mentioned: [Pg.245]    [Pg.245]    [Pg.41]    [Pg.228]    [Pg.324]    [Pg.63]    [Pg.166]    [Pg.310]    [Pg.310]    [Pg.311]    [Pg.125]    [Pg.240]    [Pg.136]    [Pg.178]    [Pg.184]    [Pg.492]    [Pg.1161]    [Pg.321]    [Pg.331]    [Pg.324]    [Pg.41]    [Pg.316]    [Pg.40]    [Pg.445]    [Pg.17]    [Pg.192]    [Pg.1276]    [Pg.53]    [Pg.194]    [Pg.558]    [Pg.559]    [Pg.228]    [Pg.103]    [Pg.400]    [Pg.456]    [Pg.602]    [Pg.585]    [Pg.29]    [Pg.103]    [Pg.128]    [Pg.94]    [Pg.298]   
See also in sourсe #XX -- [ Pg.531 ]




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