Medline-Embase

UltraLinks are not limited to unzoned text. They can be generated specifically on titles, abstract, full text publications, graphs, and chemical structures. Figure 31.3D shows a record from Medline-Embase where the abstract... 

Figure 31.3 D. Annotated record from Medline-Embase.

A search of Medline, EMBASE and PsycLIT was conducted in August 2000, using the following terms Amisulpride, clozapine, olanzapine, risperidone, sertindole, zotepine, ziprasidone, economics, healthcare, costs. All manufacturers of atypical antipsychotic drugs were contacted in April 2000 and asked to supply primary reference data on their product, and all companies had complied with this request by August 2000. A further manual search was conducted of files and journals kept in the National Centre for Information on Psychotropics at the Maudsley Hospital. Reference sections from all retrieved papers were scrutinized for further relevant references. 

Clinical studies Includes published studies and case reports describing the use of the drug(s) in patients with various types of liver disease Includes paediatric studies where available Reference 5 and Medline/Embase searches... 

International Pharmaceutical Abstracts, available electronically from 1970, from the American Society of Health-System Pharmacists, may only index around 800 journal titles but, as its name suggests, it specializes in pharmacy literature from around the world. A study by Bonnie Snow found that 12% of IPA s journals were not covered by MEDLINE, EMBASE, BIOSIS Previews, or Chemical Abstracts. IPA has also indexed ASHP meetings since 1988, meetings of the American Association of College Pharmacists and the American Pharmacy Association. All records have abstracts. 

Other abstract sources include various conference abstracts available on the Internet, such as the American Association of Cancer Research [8], the premier Biosis [9], and EMBASE [10] abstract collections. There is significant overlap between the MEDLINE, EMBASE, and Biosis abstract collections. MEDLINE is focused more on medical journals, including biology journals that support medical research. EMBASE is also focused on medical research but includes more conference abstracts and European journals. Biosis is more focused on basic life sciences. 

It is possible to access several databases at the same time (multifile searching) FIL CA,BIOSIS,MEDLINE,EMBASE... 

In the case of relevant worldwide scientific literature, the clock starts with awareness of the publication by any personnel of the marketing authorisation holder the marketing authorisation holder is expected to maintain awareness of possible publications by accessing a widely used systematic literature review and reference database, such as Medline, Excerpta Medica or Embase, no less frequently than once a week, or by making formal contractual arrangements with a second party to perform this task marketing authorisation holders are also expected to ensure that relevant publications in each Member State are appropriately reviewed. 

To ensure coverage of a broad spectrum of journals containing both original and review articles, bibliography databases, such as CAB abstracts, BIDS ISI and Embase, Medline and Current Contents Agriculture and Food Citation index, were searched. Terms used for all database searches were kept simple to limit the risk of missing any original publications (Table 4.5). Initially, each flavonoid subclass was entered and then cross-searched with the... 

This information may be gleaned from specialized ADR resources, texts, and other tertiary sources, including the FDA-approved product label. However, this information must often be augmented using additional data from secondary sources. At minimum, this should include searches of the bibliographic databases from the National Library of Medicine (Medline and Toxnet) and Excerpta Medica (Embase). 

EMBASE is the electronic form of Excerpta Medica, from the publisher Elsevier Science. It contains indexed articles from more than 4000 biomedical journals from 119 countries, although again the English language dominates. EMBASE is stronger on European and Far Eastern literature than MEDLINE. Books were also included from 1975 to 1980. The database goes back to 1974 and is updated weekly. 

The generic name, the standard being the WHO International Non-proprietary Name, is the first choice of the EMBASE indexers and for combination preparations the brand name is preferred. However, EMBASE allows drugs to be indexed under numerous names, more so than MEDLINE, and even includes the name of the manufacturer if it is in the original article. EMBASE concentrates more on the pharmacological and toxicological aspects of the biomedical literature than MEDLINE. 

The life sciences remit of BIOSIS means that it covers a wider range of scientific subjects than MEDLINE or EMBASE and has a focus on research rather than clinical practice. As a result, it is good for finding literature on early drug development. 

Brown, C.M. The benefits of searching EMBASE versus MEDLINE for pharmaceutical information. Online and CD-ROM Rev. 1998, 22 (1), 3-8. 

This study however, was hmited by its open-labeled study design. The effect of rivastigmine on neuropsychiatric symptoms and behavioral disturbance related to Alzheimer s disease was looked at by Grossberg using hterature searches published on MEDLINE and EMBASE. The result of the searches suggest that there seems to be some evidence that rivastigmine can also help with neuropsychiatric and behavioral symptoms associated with Alzheimer s disease [44],... 

MEDLINE database, known as PubMed on the NLM platform, is available free worldwide, and is considered the premier source for searching the clinical medical literature back to 1966. Embase is the other key clinical database, produced by Elsevier and known for its international scope and exceptional coverage of the drug literature. 

Based on an EMBASE and MEDLINE literature search, data from 90 studies in 4209 subjects were reviewed [13 ]. During the studies, 794 adverse effects were recorded. The most common adverse effect was fluconazole-related hepatotoxicity (47.6%), of which the majority occurred in neonates (295 out of 378 cases). Gastrointestinal symptoms including nausea, vomiting, abdominal pain, diarrhoea, dyspepsia, anorexia and gastritis accounted for 15.4% of all adverse effects. 

Life Sciences BIOSIS, CABA, CAplus, EMBASE, MEDLINE. 

INDEX BIOBUSINESS. BIOSIS, CA. CABA. CAPREVIEWS. CHEMLIST. DRUGNL. EMBASE. ENERGY. FSTA. HEALSAFE. HSDB. JICST-E. LIFESCI. MEDLINE. MSDS-CCOHS. NAPRALERT. RTECS ... 

LC STN Files ANABSTR. BEILSTEIN. BIOBUSINESS, BIOSIS, CA, CAOLD, CAPREVIEWS, CASREACT, CHEMINFORMRX, CHEMLIST, CBNB, CIN, CJACS, CSCHEM, DETHERM, EMBASE, GMELIN, HODOC, IFICDB, IFIPAT, IFIUDB, MEDLINE, NAPRALERT, PNI, RTECS, SPECINFO ( File contains numerically searchable property data)... 

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