Maudsley Hospital

A search of Medline, EMBASE and PsycLIT was conducted in August 2000, using the following terms Amisulpride, clozapine, olanzapine, risperidone, sertindole, zotepine, ziprasidone, economics, healthcare, costs. All manufacturers of atypical antipsychotic drugs were contacted in April 2000 and asked to supply primary reference data on their product, and all companies had complied with this request by August 2000. A further manual search was conducted of files and journals kept in the National Centre for Information on Psychotropics at the Maudsley Hospital. Reference sections from all retrieved papers were scrutinized for further relevant references. 

Honorary Consultant at the Maudsley Hospital and sees patients with anxiety, sleep and depressive disorders. He is on the advisory boards of about 25 international scientific journals. 

When we began using reserpine at the Maudsley Hospital less than two years ago there were very few reliable accounts of its use in the treatment of neuropsychiatric conditions and almost no controlled clinical studies. Dr D. L. Davies and I therefore conducted a clinical trial on a mixed group of out-patients, the majority of whom were suffering from anxiety and depressive reactions. The patients were given either reserpine, prescribed as Serpasil in a dose of 0.5 mg. by mouth twice daily, or a seemingly identical placebo, for a period of six weeks. The two substances... 

Two of these studies reported that the antidepressant was superior for patients with "retarded" depression, whereas the neuroleptic was superior for anxious or neurotic patients (Hollister et al. 1967 Raskin et al. 1970). This is readily understandable, given what we know of the drug-induced effects of neuroleptics. Their deactivation effects are likely to compound psychomotor retardation and reduce agitation and anxiety. Reserpine, the drug that was believed to induce a depressive state, was found to be clearly superior to placebo for the treatment of depression in an early trial conducted at the Maudsley hospital in London (Davies Shepherd 1955). 

Paklet L, Abe AM, Olajide D. Priapism associated with risperidone a case report, literature review and review of the South London and Maudsley hospital patients database. Ther Adv Psychopharmacol 2013 3(1) 3-13. 

The Maudsley Hospital Denmark Hill London SF.5 United Kingdom... 

Cooper JE, Kendell RE, Gurland BJ, et al. Psychiatric diagnosis in New York and London a comparative study of mental hospital admissions. Institute of Psychiatry, Maudsley Monographs, no. 20. London Oxford University Press, 1972. 

An excellent example of this is provided by the case of Henry Maudsley, one of the most enlightened psychiatrists of his day, and for whom a leading mental hospital in London is presently named. In his fine paper "Masturbational Insanity," E. H. Hare (1962) notes that Maudsley wrote, "In the... 

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