Major histocompatibility complex Class II antigens

Perry VH (1998) A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. J Neuroimmunol 90 113-121. 

Hess AD, hoburn C Immune tolerance to self-major histocompatibility complex class II antigens after bone marrowtransplan-tation role of regulatory cells. Biol Blood Marrow Transplant 2006 12 518-29. 

Chiu JH, Ju CH, Wu LH, Lui WY, Wu CW, Shiao MS, Hong CY. Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. Am J Chin Med 26(2) 159-170, 1998. 

Loucka J, Schlecht G, Vodolanova J et al. Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by bordetella pertussis adenylate cyclase. Infect Immun 2002 70(2) 1002-1005. 

Kaneko Y, Kuwano K, Kunitake R, et al. Immunohistochemical localization of B7 costimulating molecules and major histocompatibility complex class II antigen in pulmonary sarcoidosis. Respiration 1999 66(4) 343-348. 

Jander, S., and G. Stoll. 1996. Strain-specific expression of microglial keratan sulfate proteoglycans in the normal rat central nervous system Inverse correlation with constitutive expression of major histocompatibility complex class II antigens. Glia 18 255-260. 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

The staphylococcal superantigens initially bind to conserved elements on major histocompatibility complex class II molecules with relatively high affinity (A(i 10 mol 1 ). These receptors are found in abundance, throughout the body, on antigen-presenting cells such as macrophages and monocytes. However, each toxin... 

Superantigen target three key proteins of the adaptive immune response, namely the T cell receptor (TCR), the B cell receptor (BCR) and major histocompatibility complex class II (MHC II) proteins. All are members of the Ig superfamily, and contain domains of similar tertiary structures, although MHC II contains two non-Ig-like domains. The structure of the Ig-like domain consists of two (3-sheets, each of which comprises a series of anti-parallel (3-strands, connected by loops of varying length. Ig domain structures embody two separate functions the first is the association with antigens, with each other and with other proteins, such as Fc receptors or complement, while the second is maintenance of the structural integrity of the domain itself. 

In contrast to the conventional CD4+ and CD8+ T cells of the immune system that recognize specific peptide antigens bonnd to major histocompatibility complex class II or class I antigen presenting proteins, respectively (131-133), invariant natural killer T cells recognize glycolipid antigens presented by histocompatibility complex... 

Radsak M, Iking-Konert C, Stegmaier S, Andrassy K, Hansch GM Polymorphonuclear neutrophils as accessory cells for T-cell activation Major histocompatibility complex class II restricted antigen-dependent induction of T-cell proliferation. Immunology 2000 101 521-530. 

Lich JD, Elliott JF, Blum JS (2000) Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins. J Exp Med 191 1513-1524... 

Loss GE Jr, Elias CG, Fields PE, Ribaudo RK, McKisic M, Sant A (1993) Major histocompatibility complex class Il-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways. J Exp Med 178 73-85... 

Ia+ Murine class II major histocompatibility complex antigen IB4 Anti-CD 18 monoclonal antibody IBD Inflammatory bowel disease IBMX 3-isobutyl-l-methylxanthine IBS Inflammatory bowel syndrome iC3 Inactivated C3 iC4 Inactivated C4 IC50 Concentration producing 50% inhibition... 

An unknown antigen presented by the major histocompatibility complex (MHC) class II molecules causes T cells to become autoreactive (Fig. 26-1). Once activated, T cells penetrate the... 

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