Glycolipid antigens

Wiels, J., Junqua, S., Dujardin, P., Le Pecq, J.B., and Tursz, T. (1984) Properties of immunotoxins against a glycolipid antigen associated with Burkitt s lymphoma. Cancer Res. 44, 129. 

Symington, F.W., Hedges, D.L. and Hakomori, S. (1985) Glycolipid antigens of human polymorphonuclear neutrophils and the inducible HL-60 myeloid leukemia line. Journal of Immunology 134, 2498-2506. 

Wuhrer, M., Dennis, R.D., Doenhoff, M.J., Bickle, Q., Lochnit, G. and Geyer, R. (1999) Immunochemical characterisation of Schistosoma mansoni glycolipid antigens. Molecular and Biochemical Parasitology 103, 155-169. 

Inokuchi, J., Momosaki, K., Shimeno, H., Nagamatsu, A., and Radin, N. S. (1989). Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells. J. Cell. Physiol. 141, 573—583. 

The structures, synthesis, and some of the biological properties of these three major classes of mycobacterial glycolipid antigens are the basis of this article. 

Kniep, B., Flegel, W.A., Northoff, H., andRieber, E.P., CDw60 glycolipid antigens of human leukocytes structural characterization and cellular distribution, Blood, 82, 1776, 1993. 

Acute autoimmune demyelinating polyneuropathies such as Guillain-Barre syndrome and chronic polyneuropathies may involve some glycolipid antigens, as described later. 

Cheung NK, Saarinen UM, Neely JE, Landmeier B, Donovan D, Coccia PF (1985) Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells. Cancer Res 45 2642-2649... 

Figure 1. Presentation of peptide antigens and l id/glycolipid antigens to T lymphocytes.

Figure 2. Structures of exogeneous and endogeneous glycolipid antigens...

Sjoberg, K., Hosein, Z., Wahlin, B. et al. (1991) Plasmodium falciparum-an invasion inhibitory human monoclonal antibody is directed against a malarial glycolipid antigen. Exp. Parasitol. 73 317 325. 

Rosen, G., Londner, M. V., Sevlever, D. and Greenblatt, C. L. (1988) Leishmania major Glycolipid antigens recognized by immune human sera. Mol. Biochem. Parasitol. IT. 93-100. 

In contrast to the conventional CD4+ and CD8+ T cells of the immune system that recognize specific peptide antigens bonnd to major histocompatibility complex class II or class I antigen presenting proteins, respectively (131-133), invariant natural killer T cells recognize glycolipid antigens presented by histocompatibility complex... 

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